Man1a2 mannosidase, alpha, class 1A, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Man1a2provided by RGD
Official Full Name: mannosidase, alpha, class 1A, member 2provided by RGD
Primary source: RGD:1309767
See related: EnsemblRapid:ENSRNOG00000015226 AllianceGenome:RGD:1309767
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Man1b
Summary: Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in ERAD pathway. Predicted to act upstream of or within glycoprotein metabolic process; lung alveolus development; and respiratory gaseous exchange by respiratory system. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane and endoplasmic reticulum. Orthologous to human MAN1A2 (mannosidase alpha class 1A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 210.2), Lung (RPKM 185.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (190636134..190784975, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (187947484..188096332, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (202891537..203043847, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH136810 (e-PCR)
- UniSTS:218899

RH141555 (e-PCR)
- UniSTS:223549

AW532536 (e-PCR)
- UniSTS:245585

AA945034 (e-PCR)
- UniSTS:250197

RH139474 (e-PCR)
- UniSTS:221560

RH138306 (e-PCR)
- UniSTS:220393

BQ195426 (e-PCR)
- UniSTS:261887

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

Names: mannosidase 1, beta

NP_001099922.1

EC 3.2.1.113

XP_038957988.1

EC 3.2.1.113

XP_038957989.2

EC 3.2.1.113

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106452.1 → NP_001099922.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

See identical proteins and their annotated locations for NP_001099922.1

Status: PROVISIONAL

Source sequence(s)

CH474015

UniProtKB/TrEMBL

A0A8I6ANZ7, A6K3G6, D3ZR49

Related

ENSRNOP00000060243.4, ENSRNOT00000067000.5

Conserved Domains (2) summary

pfam01532
Location:187 → 626

Glyco_hydro_47; Glycosyl hydrolase family 47

cl21478
Location:107 → 151

ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

190636134..190784975 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102060.2 → XP_038957988.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IB isoform X1

UniProtKB/TrEMBL

A0A8I6ANZ7

Conserved Domains (2) summary

PTZ00121
Location:3 → 109

PTZ00121; MAEBL; Provisional

pfam01532
Location:88 → 527

Glyco_hydro_47; Glycosyl hydrolase family 47
XM_039102061.2 → XP_038957989.2 mannosyl-oligosaccharide 1,2-alpha-mannosidase IB isoform X2