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    Ubqln2 ubiquilin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317396, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ubqln2provided by RGD
    Official Full Name
    ubiquilin 2provided by RGD
    Primary source
    RGD:1563566
    See related
    EnsemblRapid:ENSRNOG00000003099 AllianceGenome:RGD:1563566
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563566
    Summary
    Predicted to enable identical protein binding activity; molecular condensate scaffold activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including negative regulation of receptor-mediated endocytosis; positive regulation of ERAD pathway; and proteolysis involved in protein catabolic process. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 15. Orthologous to human UBQLN2 (ubiquilin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See Ubqln2 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (21228809..21232228, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (17853086..17856505, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (18723313..18726732, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerisation domain containing 12b Neighboring gene negative regulator of P-body association Neighboring gene KLF transcription factor 8 Neighboring gene ribosomal protein L35, pseudogene 8 Neighboring gene uncharacterized LOC100909694 Neighboring gene Ras-related GTP binding B

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of G protein-coupled receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108251.2NP_001101721.1  ubiquilin-2

      See identical proteins and their annotated locations for NP_001101721.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6KL57, D4AA63
      Related
      ENSRNOP00000026214.5, ENSRNOT00000026214.8
      Conserved Domains (4) summary
      smart00727
      Location:393440
      STI1; Heat shock chaperonin-binding motif
      cd01808
      Location:33103
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      smart00213
      Location:33103
      UBQ; Ubiquitin homologues
      cd14399
      Location:595634
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      21228809..21232228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)