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    Mycbp2 MYC binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290447, updated on 3-Dec-2024

    Summary

    Symbol
    Mycbp2provided by RGD
    Full Name
    MYC binding protein 2provided by RGD
    Primary source
    RGD:1312048
    See related
    EnsemblRapid:ENSRNOG00000010479 AllianceGenome:RGD:1312048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pam; Phr1
    Summary
    Predicted to enable several functions, including guanyl-nucleotide exchange factor activity; small GTPase binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including circadian regulation of gene expression; protein K48-linked ubiquitination; and regulation of synaptic assembly at neuromuscular junction. Predicted to act upstream of or within several processes, including axonogenesis; negative regulation of protein catabolic process; and regulation of cytoskeleton organization. Predicted to be located in several cellular components, including axon; microtubule cytoskeleton; and nucleoplasm. Predicted to be active in nucleus and plasma membrane. Orthologous to human MYCBP2 (MYC binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 368.4), Brain (RPKM 313.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mycbp2 in Genome Data Viewer
    Location:
    15q21
    Exon count:
    86
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (86352061..86590126, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (79937354..80175432, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (93678062..93901556, complement) , (87405472..87450812, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352966 Neighboring gene CLN5, intracellular trafficking protein Neighboring gene F-box and leucine-rich repeat protein 3 Neighboring gene cytochrome c, somatic pseudogene Neighboring gene uncharacterized LOC108352959 Neighboring gene uncharacterized LOC102550034 Neighboring gene uncharacterized LOC100909907

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within branchiomotor neuron axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within central nervous system projection neuron axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system projection neuron axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within motor neuron axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic assembly at neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MYCBP2
    Names
    E3 ubiquitin-protein ligase MYCBP2-like
    MYC binding protein 2, E3 ubiquitin protein ligase
    pam, highwire, rpm 1
    probable E3 ubiquitin-protein ligase MYCBP2
    probable E3 ubiquitin-protein ligase MYCBP2-like
    protein associated with Myc
    NP_001099525.2
    XP_038949112.2
    XP_038949114.2
    XP_038949115.2
    XP_038949116.2
    XP_038949117.2
    XP_038949118.2
    XP_038949119.2
    XP_038949120.2
    XP_038949121.2
    XP_038949122.2
    XP_038949123.2
    XP_038949124.2
    XP_038949125.1
    XP_038949126.1
    XP_063130239.1
    XP_063130241.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106055.2NP_001099525.2  E3 ubiquitin-protein ligase MYCBP2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6A2N3, A0A8I6A4L1
      Related
      ENSRNOP00000085907.2, ENSRNOT00000099831.2
      Conserved Domains (8) summary
      smart00557
      Location:23922443
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5184
      Location:6831024
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:9581006
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam08005
      Location:17241879
      PHR; PHR domain
      pfam08239
      Location:24772537
      SH3_3; Bacterial SH3 domain
      pfam13540
      Location:943971
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
      pfam13639
      Location:44974550
      zf-RING_2; Ring finger domain
      cl02148
      Location:38223914
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      86352061..86590126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274171.1XP_063130241.1  E3 ubiquitin-protein ligase MYCBP2 isoform X14

      UniProtKB/TrEMBL
      A0A8I6AJ55
      Related
      ENSRNOP00000092896.1, ENSRNOT00000109278.2
    2. XM_039093195.2XP_038949123.2  E3 ubiquitin-protein ligase MYCBP2 isoform X12

      UniProtKB/TrEMBL
      A0A8I6AJ55
    3. XM_039093194.2XP_038949122.2  E3 ubiquitin-protein ligase MYCBP2 isoform X11

      UniProtKB/TrEMBL
      A0A1W2Q679
      Related
      ENSRNOP00000076173.2, ENSRNOT00000093546.3
    4. XM_039093192.2XP_038949120.2  E3 ubiquitin-protein ligase MYCBP2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6A4L1
      Related
      ENSRNOP00000085773.1, ENSRNOT00000112777.2
    5. XM_039093191.2XP_038949119.2  E3 ubiquitin-protein ligase MYCBP2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A4L1
    6. XM_039093196.2XP_038949124.2  E3 ubiquitin-protein ligase MYCBP2 isoform X13

      UniProtKB/TrEMBL
      A0A1W2Q679
    7. XM_039093193.2XP_038949121.2  E3 ubiquitin-protein ligase MYCBP2 isoform X10

      UniProtKB/TrEMBL
      A0A1W2Q679
    8. XM_039093190.2XP_038949118.2  E3 ubiquitin-protein ligase MYCBP2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A4L1
      Related
      ENSRNOP00000076104.2, ENSRNOT00000093370.3
    9. XM_039093189.2XP_038949117.2  E3 ubiquitin-protein ligase MYCBP2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A4L1
    10. XM_039093188.2XP_038949116.2  E3 ubiquitin-protein ligase MYCBP2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A4L1
    11. XM_063274169.1XP_063130239.1  E3 ubiquitin-protein ligase MYCBP2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A4L1
    12. XM_039093186.2XP_038949114.2  E3 ubiquitin-protein ligase MYCBP2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4L1
    13. XM_039093187.2XP_038949115.2  E3 ubiquitin-protein ligase MYCBP2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A4L1
    14. XM_039093184.2XP_038949112.2  E3 ubiquitin-protein ligase MYCBP2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4L1
    15. XM_039093197.2XP_038949125.1  E3 ubiquitin-protein ligase MYCBP2 isoform X15

      UniProtKB/TrEMBL
      A0A1W2Q616
      Conserved Domains (8) summary
      COG5184
      Location:683988
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd16463
      Location:44754529
      RING-H2_PHR; RING finger, H2 subclass, found in the PHR protein family
      cd19799
      Location:43094357
      Bbox2_MYCBP2; B-box-type 2 zinc finger found in Myc-binding protein 2 (MYCBP2) and similar proteins
      cl02148
      Location:37983890
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      pfam00415
      Location:922970
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam08005
      Location:11991349
      PHR; PHR domain
      pfam08239
      Location:24422504
      SH3_3; Bacterial SH3 domain
      cl27659
      Location:23592410
      Filamin; Filamin/ABP280 repeat
    16. XM_039093198.2XP_038949126.1  E3 ubiquitin-protein ligase MYCBP2 isoform X16

      Conserved Domains (5) summary
      cd16463
      Location:23142368
      RING-H2_PHR; RING finger, H2 subclass, found in the PHR protein family
      cd19799
      Location:21482196
      Bbox2_MYCBP2; B-box-type 2 zinc finger found in Myc-binding protein 2 (MYCBP2) and similar proteins
      cl02148
      Location:16371729
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      pfam08239
      Location:281343
      SH3_3; Bacterial SH3 domain
      cl27659
      Location:198249
      Filamin; Filamin/ABP280 repeat