Adi1 acireductone dioxygenase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adi1provided by RGD
Official Full Name: acireductone dioxygenase 1provided by RGD
Primary source: RGD:727828
See related: AllianceGenome:RGD:727828
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ARD'; Alp1; Fe-ARD; Ni-ARD; MTCBP-1
Summary: Predicted to enable acireductone dioxygenase [iron(II)-requiring] activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Orthologous to human ADI1 (acireductone dioxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 395.6), Kidney (RPKM 291.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (51035267..51042229)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (45306885..45313847)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (47940211..47947173)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

May have an important role in androgen regulated prostate homeostasis as well as in prostate cancer progression by regulating cell death of prostate cancer cells.
Title: Identification and characterization of an androgen-responsive gene encoding an aci-reductone dioxygenase-like protein in the rat prostate.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acireductone dioxygenase (Ni2+-requiring) activity	IEA Inferred from Electronic Annotation more info
enables acireductone dioxygenase [iron(II)-requiring] activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables nickel cation binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-methionine salvage from methylthioadenosine	IEA Inferred from Electronic Annotation more info
involved_in L-methionine salvage from methylthioadenosine	ISO Inferred from Sequence Orthology more info
involved_in L-methionine salvage from methylthioadenosine	ISS Inferred from Sequence or Structural Similarity more info
involved_in methionine metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: acireductone dioxygenase

Names: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; ARD; aci-reductone dioxygenase (ARD)-like protein 1; acireductone dioxygenase (Fe(2+)-requiring); acireductone dioxygenase (Ni(2+)-requiring); androgen-responsive ARD-like protein 1; androgen-responsive gene encoding an ARD-like protein; membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1

NP_954528.2

EC 1.13.11.53

EC 1.13.11.54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199097.2 → NP_954528.2 acireductone dioxygenase

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q562C9, Q6V9S4

UniProtKB/TrEMBL

A6HB14

Conserved Domains (1) summary

cd02232
Location:28 → 157

cupin_ARD; acireductone dioxygenase (ARD), cupin domain