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    Arfgap3 ARF GTPase activating protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 503165, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arfgap3provided by RGD
    Official Full Name
    ARF GTPase activating protein 3provided by RGD
    Primary source
    RGD:1560066
    See related
    EnsemblRapid:ENSRNOG00000046472 AllianceGenome:RGD:1560066
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in COPI coating of Golgi vesicle; presynaptic endocytosis; and protein secretion. Predicted to be located in Golgi apparatus; cytosol; and presynapse. Predicted to be active in photoreceptor ribbon synapse and presynaptic active zone. Orthologous to human ARFGAP3 (ADP ribosylation factor GTPase activating protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 108.0), Kidney (RPKM 105.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arfgap3 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116312996..116359300, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114432873..114479206, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124149665..124198298, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cytochrome b5 reductase 3 Neighboring gene alpha 1,4-galactosyltransferase Neighboring gene protein kinase C and casein kinase substrate in neurons 2 Neighboring gene uncharacterized LOC120093699

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of novel human ARFGAP3. Liu X, et al. FEBS Lett, 2001 Feb 9. PMID 11172815
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116119

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPI coating of Golgi vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in presynaptic endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in photoreceptor ribbon synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor GTPase-activating protein 3
    Names
    ADP-ribosylation factor GTPase activating protein 3
    ARF GAP 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044273.1 → NP_001037738.1  ADP-ribosylation factor GTPase-activating protein 3

      See identical proteins and their annotated locations for NP_001037738.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099081
      UniProtKB/Swiss-Prot
      Q4KLN7
      UniProtKB/TrEMBL
      A0A0G2K4J0
      Related
      ENSRNOP00000065256.4, ENSRNOT00000074960.4
      Conserved Domains (2) summary
      PLN03114
      Location:1 → 488
      PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
      pfam01412
      Location:11 → 121
      ArfGap; Putative GTPase activating protein for Arf

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      116312996..116359300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079783.2 → XP_038935711.1  ADP-ribosylation factor GTPase-activating protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K4J0
      Conserved Domains (2) summary
      PLN03114
      Location:1 → 487
      PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
      cd09028
      Location:4 → 123
      ArfGap_ArfGap3; Arf1 GTPase-activating protein 3

    2. XM_063264156.1 → XP_063120226.1  ADP-ribosylation factor GTPase-activating protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4J0

    3. XM_063264154.1 → XP_063120224.1  ADP-ribosylation factor GTPase-activating protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4J0

    4. XM_039079782.2 → XP_038935710.1  ADP-ribosylation factor GTPase-activating protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K4J0
      Conserved Domains (2) summary
      PLN03114
      Location:1 → 487
      PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
      cd09028
      Location:4 → 123
      ArfGap_ArfGap3; Arf1 GTPase-activating protein 3

    5. XM_039079784.2 → XP_038935712.1  ADP-ribosylation factor GTPase-activating protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K4J0
      Conserved Domains (2) summary
      PLN03114
      Location:1 → 486
      PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
      cd09028
      Location:4 → 123
      ArfGap_ArfGap3; Arf1 GTPase-activating protein 3

    6. XM_063264155.1 → XP_063120225.1  ADP-ribosylation factor GTPase-activating protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4J0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KLN7.1 GenPept UniProtKB/Swiss-Prot:Q4KLN7

    Gene LinkOut

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