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    Aox4 aldehyde oxidase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316424, updated on 27-Nov-2024

    Summary

    Official Symbol
    Aox4provided by RGD
    Official Full Name
    aldehyde oxidase 4provided by RGD
    Primary source
    RGD:1311975
    See related
    EnsemblRapid:ENSRNOG00000085989 AllianceGenome:RGD:1311975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aoh2; Aa2-245; RGD1311975
    Summary
    Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; molybdopterin cofactor binding activity; and protein homodimerization activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 5.5), Lung (RPKM 4.1) and 5 other tissues See more
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    Genomic context

    See Aox4 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67255437..67312364)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (59761238..59818169)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65110330..65167188)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene aldehyde oxidase 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene protein tyrosine phosphatase 4A1, pseudogene 5 Neighboring gene uncharacterized LOC103690538 Neighboring gene ribosomal protein L21 like 4 Neighboring gene aldehyde oxidase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables 2 iron, 2 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables aldehyde oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aldehyde oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables aldehyde oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables flavin adenine dinucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molybdopterin cofactor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in xenobiotic metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    aldehyde oxidase 4
    Names
    aldehyde oxidase homolog 2
    azaheterocycle hydroxylase 4
    retinal oxidase
    NP_001008523.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008523.2NP_001008523.2  aldehyde oxidase 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5QE79
      UniProtKB/TrEMBL
      A0A0G2QC16
      Related
      ENSRNOP00000035377.7, ENSRNOT00000033068.7
      Conserved Domains (1) summary
      TIGR02969
      Location:71332
      mam_aldehyde_ox; aldehyde oxidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      67255437..67312364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)