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    Irf7 interferon regulatory factor 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293624, updated on 9-Dec-2024

    Summary

    Official Symbol
    Irf7provided by RGD
    Official Full Name
    interferon regulatory factor 7provided by RGD
    Primary source
    RGD:1307828
    See related
    EnsemblRapid:ENSRNOG00000017414 AllianceGenome:RGD:1307828
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of macromolecule biosynthetic process; and regulation of innate immune response. Predicted to act upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon production; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 506.0), Lung (RPKM 159.4) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Irf7 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205796956..205800543, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196367380..196370943, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214249388..214252909, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553043 Neighboring gene microRNA 3574 Neighboring gene microRNA 210 Neighboring gene PHD and ring finger domains 1 Neighboring gene cadherin-related family member 5 Neighboring gene secretin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC125013

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cytoplasmic pattern recognition receptor signaling pathway  
    involved_in defense response to virus  
    involved_in immune system process  
    acts_upstream_of_or_within immunoglobulin mediated immune response  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of interferon-alpha production  
    involved_in positive regulation of interferon-beta production  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of type I interferon production  
    involved_in positive regulation of type I interferon production  
    acts_upstream_of_or_within positive regulation of type I interferon-mediated signaling pathway  
    involved_in regulation of MyD88-dependent toll-like receptor signaling pathway  
    involved_in regulation of MyD88-independent toll-like receptor signaling pathway  
    involved_in regulation of adaptive immune response  
    acts_upstream_of_or_within regulation of gene expression  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in type I interferon-mediated signaling pathway  
    Component Evidence Code Pubs
    is_active_in chromatin  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    interferon regulatory factor 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033691.1NP_001028863.1  interferon regulatory factor 7

      See identical proteins and their annotated locations for NP_001028863.1

      Status: PROVISIONAL

      Source sequence(s)
      BC104686
      UniProtKB/TrEMBL
      F7FGY2, Q3SWU2
      Related
      ENSRNOP00000023504.6, ENSRNOT00000023504.8
      Conserved Domains (2) summary
      pfam00605
      Location:11121
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:240418
      IRF-3; Interferon-regulatory factor 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205796956..205800543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230540.3XP_006230602.1  interferon regulatory factor 7 isoform X1

      See identical proteins and their annotated locations for XP_006230602.1

      UniProtKB/TrEMBL
      F7FGY2, Q3SWU2
      Conserved Domains (2) summary
      pfam00605
      Location:11121
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:240418
      IRF-3; Interferon-regulatory factor 3
    2. XM_006230541.2XP_006230603.1  interferon regulatory factor 7 isoform X2

      Conserved Domains (2) summary
      pfam00605
      Location:11121
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:208386
      IRF-3; Interferon-regulatory factor 3
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