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    Rint1 RAD50 interactor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296750, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rint1provided by RGD
    Official Full Name
    RAD50 interactor 1provided by RGD
    Primary source
    RGD:1560433
    See related
    EnsemblRapid:ENSRNOG00000022182 AllianceGenome:RGD:1560433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560433
    Summary
    Predicted to be involved in mitotic G2 DNA damage checkpoint signaling; regulation of ER to Golgi vesicle-mediated transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum. Predicted to be part of Dsl1/NZR complex. Human ortholog(s) of this gene implicated in infantile liver failure syndrome. Orthologous to human RINT1 (RAD50 interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 71.6), Adrenal (RPKM 66.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rint1 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (12211806..12248117, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (11319416..11355740, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7851602..7885446, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909675 Neighboring gene small nucleolar RNA, C/D box 93 Neighboring gene translocase of outer mitochondrial membrane 7 Neighboring gene pseudouridine synthase 7 Neighboring gene small nucleolar RNA SNORD93

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control. Xiao J, et al. J Biol Chem, 2001 Mar 2. PMID 11096100
    2. RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex. Arasaki K, et al. Mol Biol Cell, 2006 Jun. PMID 16571679, Free PMC Article
    3. Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery. Civril F, et al. Structure, 2010 May 12. PMID 20462495
    4. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. Hirose H, et al. EMBO J, 2004 Mar 24. PMID 15029241, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ER to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ER to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Dsl1/NZR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Dsl1/NZR complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RAD50-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399263.1 → NP_001386192.1  RAD50-interacting protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5ZVY6, A6K582, D4A4T6
      Related
      ENSRNOP00000082957.1, ENSRNOT00000106589.2
      Conserved Domains (1) summary
      pfam04437
      Location:304 → 784
      RINT1_TIP1; RINT-1 / TIP-1 family

    2. NM_001399264.1 → NP_001386193.1  RAD50-interacting protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      Conserved Domains (1) summary
      pfam04437
      Location:125 → 605
      RINT1_TIP1; RINT-1 / TIP-1 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      12211806..12248117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285696.1 → XP_063141766.1  RAD50-interacting protein 1 isoform X1

    2. XM_039108555.2 → XP_038964483.1  RAD50-interacting protein 1 isoform X2

      Conserved Domains (1) summary
      pfam04437
      Location:1 → 476
      RINT1_TIP1; RINT-1 / TIP-1 family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
    Research Materials