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    Cenpf centromere protein F [ Rattus norvegicus (Norway rat) ]

    Gene ID: 257649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cenpfprovided by RGD
    Official Full Name
    centromere protein Fprovided by RGD
    Primary source
    RGD:628667
    See related
    EnsemblRapid:ENSRNOG00000003388 AllianceGenome:RGD:628667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lek1
    Summary
    Predicted to enable DNA-binding transcription factor binding activity; dynein complex binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including metaphase chromosome alignment; regulation of G2/M transition of mitotic cell cycle; and ventricular system development. Predicted to act upstream of or within regulation of striated muscle tissue development. Predicted to be located in several cellular components, including cytoskeleton; midbody; and nucleus. Predicted to be part of ciliary transition fiber and outer kinetochore. Predicted to be active in chromosome, centromeric region; nucleus; and spindle pole. Human ortholog(s) of this gene implicated in Stromme syndrome. Orthologous to human CENPF (centromere protein F). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 202.4), Spleen (RPKM 142.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cenpf in Genome Data Viewer
    Location:
    13q26
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (103715344..103760931, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (101184127..101229714, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (108132499..108178609, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548648 Neighboring gene transmembrane protein 14C like 1 Neighboring gene potassium two pore domain channel subfamily K member 2 Neighboring gene wiskott-Aldrich syndrome protein homolog 1-like Neighboring gene protein tyrosine phosphatase, non-receptor type 14 Neighboring gene SET and MYND domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Therapeutic effects of acupuncture in rheumatoid arthritis are associated with centromere protein F expression. Dong W, et al. Allergol Immunopathol (Madr), 2022. PMID 35527655
    2. CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization. Rattner JB, et al. Cell Motil Cytoskeleton, 1993. PMID 7904902
    3. Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F. Bomont P, et al. EMBO J, 2005 Nov 16. PMID 16252009, Free PMC Article
    4. The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization. Zhu X, et al. J Biol Chem, 1995 Aug 18. PMID 7642639
    5. Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Yang Z, et al. Mol Cell Biol, 2005 May. PMID 15870278, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Therapeutic effects of acupuncture in rheumatoid arthritis are associated with centromere protein F expression.
      Title: Therapeutic effects of acupuncture in rheumatoid arthritis are associated with centromere protein F expression.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of striated muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ventricular system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ciliary transition fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pronucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centromere protein F
    Names
    LEK/centromere protein
    centromere autoantigen F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100827.2 → NP_001094297.2  centromere protein F isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JGV8, E9PT83

    2. NM_001433858.1 → NP_001420787.1  centromere protein F isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JGV8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      103715344..103760931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090400.2 → XP_038946328.1  centromere protein F isoform X2

      Conserved Domains (5) summary
      COG1196
      Location:1917 → 2692
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:285 → 1108
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10473
      Location:2293 → 2432
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam10481
      Location:1 → 297
      CENP-F_N; Cenp-F N-terminal domain
      pfam10490
      Location:2846 → 2879
      CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1

    2. XM_039090398.2 → XP_038946326.1  centromere protein F isoform X1

      UniProtKB/TrEMBL
      A6JGV8
      Related
      ENSRNOP00000004525.8, ENSRNOT00000004525.8
      Conserved Domains (6) summary
      COG1196
      Location:1917 → 2692
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:285 → 1108
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10473
      Location:2293 → 2432
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam10481
      Location:1 → 297
      CENP-F_N; Cenp-F N-terminal domain
      pfam10490
      Location:2851 → 2884
      CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1
      cl27170
      Location:1517 → 1661
      DUF460; Protein of unknown function (DUF460)

    3. XM_039090399.2 → XP_038946327.1  centromere protein F isoform X1

      UniProtKB/TrEMBL
      A6JGV8
      Conserved Domains (6) summary
      COG1196
      Location:1917 → 2692
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:285 → 1108
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10473
      Location:2293 → 2432
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam10481
      Location:1 → 297
      CENP-F_N; Cenp-F N-terminal domain
      pfam10490
      Location:2851 → 2884
      CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1
      cl27170
      Location:1517 → 1661
      DUF460; Protein of unknown function (DUF460)

    4. XM_063272055.1 → XP_063128125.1  centromere protein F isoform X3

      UniProtKB/TrEMBL
      A6JGV8
    Nucleotide Protein Strain
    Heading Accession and Version

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