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    Slc16a10 solute carrier family 16 member 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170566, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc16a10provided by RGD
    Official Full Name
    solute carrier family 16 member 10provided by RGD
    Primary source
    RGD:69197
    See related
    EnsemblRapid:ENSRNOG00000000588 AllianceGenome:RGD:69197
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tat1
    Summary
    Enables L-phenylalanine transmembrane transporter activity; L-tryptophan transmembrane transporter activity; and L-tyrosine transmembrane transporter activity. Involved in aromatic amino acid transport. Located in basolateral plasma membrane. Orthologous to human SLC16A10 (solute carrier family 16 member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 100.9), Kidney (RPKM 85.3) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc16a10 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (45014229..45122392, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (43454819..43567839, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (45138433..45260155, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene Na+ dependent glucose transporter 1 Neighboring gene major facilitator superfamily domain containing 4B2 like 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108349085 Neighboring gene small nucleolar RNA, H/ACA box 69 Neighboring gene ribosome production factor 2 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. Kim DK, et al. J Biol Chem, 2001 May 18. PMID 11278508
    2. Tissue-based metabolomics reveals metabolic biomarkers and potential therapeutic targets for esophageal squamous cell carcinoma. Chen Z, et al. J Pharm Biomed Anal, 2021 Apr 15. PMID 33609949
    3. Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency. Müller J, et al. Endocrinology, 2014 Jan. PMID 24248460
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-phenylalanine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-phenylalanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-tryptophan transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-tryptophan transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-tyrosine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-tyrosine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aromatic amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aromatic amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thyroid hormone transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thyroid hormone transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aromatic amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in aromatic amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocarboxylic acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylalanine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_negative_effect thyroid hormone generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within thyroid hormone transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within_negative_effect thyroid-stimulating hormone secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 10
    Names
    MCT 10
    T-type amino acid transporter 1
    aromatic amino acid transporter 1
    solute carrier family 16 (aromatic amino acid transporter), member 10
    solute carrier family 16 (monocarboxylic acid transporters), member 10
    solute carrier family 16, member 10 (aromatic amino acid transporter)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138831.1 → NP_620186.1  monocarboxylate transporter 10

      See identical proteins and their annotated locations for NP_620186.1

      Status: PROVISIONAL

      Source sequence(s)
      AB047324
      UniProtKB/Swiss-Prot
      G3V621, Q91Y77
      Related
      ENSRNOP00000000718.4, ENSRNOT00000000718.7
      Conserved Domains (2) summary
      cd06174
      Location:70 → 469
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:60 → 481
      2A0113; monocarboxylate transporter 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      45014229..45122392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098394.2 → XP_038954322.1  monocarboxylate transporter 10 isoform X1

      UniProtKB/Swiss-Prot
      G3V621, Q91Y77
      UniProtKB/TrEMBL
      A0A0G2KAT0
      Related
      ENSRNOP00000075512.2, ENSRNOT00000087226.3
      Conserved Domains (2) summary
      NF033930
      Location:3 → 64
      pneumo_PspA; pneumococcal surface protein A
      cl28910
      Location:69 → 421
      MFS; Major Facilitator Superfamily

    2. XM_039098395.2 → XP_038954323.1  monocarboxylate transporter 10 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:1 → 349
      MFS; Major Facilitator Superfamily

    3. XM_063278943.1 → XP_063135013.1  monocarboxylate transporter 10 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91Y77.2 GenPept UniProtKB/Swiss-Prot:Q91Y77

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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