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    Ppp1r9a protein phosphatase 1, regulatory subunit 9A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84685, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ppp1r9aprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 9Aprovided by RGD
    Primary source
    RGD:632280
    See related
    EnsemblRapid:ENSRNOG00000008869 AllianceGenome:RGD:632280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Neb1; p180; PP1bp175
    Summary
    Enables several functions, including actin filament binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of actin filament organization; and regulation of synapse organization. Acts upstream of or within neuron projection development. Located in several cellular components, including dendritic spine neck; growth cone lamellipodium; and neuromuscular junction. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Used to study transient cerebral ischemia. Biomarker of hepatocellular carcinoma. Orthologous to human PPP1R9A (protein phosphatase 1 regulatory subunit 9A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 210.6), Testes (RPKM 72.0) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppp1r9a in Genome Data Viewer
    Location:
    4q21
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (33936949..34258927)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (32970501..33292360)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (29976485..30247371)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene cytoskeleton-associated protein 2, pseudogene 1 Neighboring gene paraoxonase 1 Neighboring gene paraoxonase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase 1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to toxic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of spontaneous neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynaptic actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synapse structural plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine neck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    neurabin-1
    Names
    actin-binding protein neurabin
    neurabin-I
    neural tissue-specific F-actin-binding protein I
    protein phosphatase 1, regulatory (inhibitor) subunit 9A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401497.1NP_001388426.1  neurabin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      Related
      ENSRNOP00000078577.3, ENSRNOT00000104466.3
      Conserved Domains (4) summary
      cd09512
      Location:12081277
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00228
      Location:502593
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      TIGR02168
      Location:681920
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17817
      Location:435498
      PDZ_5; PDZ domain
    2. NM_053473.3NP_445925.1  neurabin-1 isoform 2

      See identical proteins and their annotated locations for NP_445925.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      O35867
      UniProtKB/TrEMBL
      A6IDS9
      Conserved Domains (4) summary
      cd09512
      Location:9831052
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      cd00992
      Location:506589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02168
      Location:659904
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17817
      Location:435498
      PDZ_5; PDZ domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      33936949..34258927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108474.2XP_038964402.1  neurabin-1 isoform X1

      Conserved Domains (4) summary
      cd09512
      Location:12081277
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00228
      Location:502593
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      TIGR02168
      Location:681920
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17817
      Location:435498
      PDZ_5; PDZ domain
    2. XM_063286778.1XP_063142848.1  neurabin-1 isoform X10

    3. XM_063286768.1XP_063142838.1  neurabin-1 isoform X2

      UniProtKB/TrEMBL
      A6IDS7
    4. XM_063286775.1XP_063142845.1  neurabin-1 isoform X8

    5. XM_063286770.1XP_063142840.1  neurabin-1 isoform X4

      Related
      ENSRNOP00000098611.2, ENSRNOT00000121068.2
    6. XM_063286772.1XP_063142842.1  neurabin-1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZL80
    7. XM_063286780.1XP_063142850.1  neurabin-1 isoform X11

    8. XM_006236058.5XP_006236120.1  neurabin-1 isoform X1

      See identical proteins and their annotated locations for XP_006236120.1

      Conserved Domains (4) summary
      cd09512
      Location:12081277
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00228
      Location:502593
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      TIGR02168
      Location:681920
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17817
      Location:435498
      PDZ_5; PDZ domain
    9. XM_039108475.2XP_038964403.1  neurabin-1 isoform X2

      UniProtKB/TrEMBL
      A6IDS7
      Conserved Domains (5) summary
      cd09512
      Location:12001269
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00228
      Location:502593
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      TIGR02168
      Location:681920
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09730
      Location:606752
      BicD; Microtubule-associated protein Bicaudal-D
      pfam17817
      Location:435498
      PDZ_5; PDZ domain
    10. XM_039108479.2XP_038964407.1  neurabin-1 isoform X7

      Related
      ENSRNOP00000011756.5, ENSRNOT00000011756.7
      Conserved Domains (5) summary
      cd09512
      Location:10051074
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      cd00992
      Location:506589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02168
      Location:681920
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09730
      Location:606752
      BicD; Microtubule-associated protein Bicaudal-D
      pfam17817
      Location:435498
      PDZ_5; PDZ domain
    11. XM_039108480.2XP_038964408.1  neurabin-1 isoform X8

      Conserved Domains (5) summary
      cd09512
      Location:9971066
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      cd00992
      Location:506589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02168
      Location:681920
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09730
      Location:606752
      BicD; Microtubule-associated protein Bicaudal-D
      pfam17817
      Location:435498
      PDZ_5; PDZ domain
    12. XM_039108476.2XP_038964404.1  neurabin-1 isoform X3

      Conserved Domains (4) summary
      cd09512
      Location:11901259
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00228
      Location:502593
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG1196
      Location:704819
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17817
      Location:435498
      PDZ_5; PDZ domain
    13. XM_039108477.2XP_038964405.1  neurabin-1 isoform X4

      Conserved Domains (4) summary
      cd09512
      Location:11861255
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00228
      Location:502593
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      TIGR02168
      Location:659898
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17817
      Location:435498
      PDZ_5; PDZ domain
    14. XM_039108481.2XP_038964409.1  neurabin-1 isoform X9

      UniProtKB/Swiss-Prot
      O35867
      UniProtKB/TrEMBL
      A6IDS9
      Related
      ENSRNOP00000098612.2, ENSRNOT00000121069.2
      Conserved Domains (4) summary
      cd09512
      Location:9831052
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      cd00992
      Location:506589
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR02168
      Location:659904
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17817
      Location:435498
      PDZ_5; PDZ domain
    15. XM_063286773.1XP_063142843.1  neurabin-1 isoform X6

    16. XM_063286779.1XP_063142849.1  neurabin-1 isoform X11

    17. XM_017592928.3XP_017448417.1  neurabin-1 isoform X1

      Conserved Domains (4) summary
      cd09512
      Location:12081277
      SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily
      smart00228
      Location:502593
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      TIGR02168
      Location:681920
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17817
      Location:435498
      PDZ_5; PDZ domain
    18. XM_063286771.1XP_063142841.1  neurabin-1 isoform X4

    19. XM_063286777.1XP_063142847.1  neurabin-1 isoform X9

      UniProtKB/Swiss-Prot
      O35867
      UniProtKB/TrEMBL
      A6IDS9
    20. XM_063286774.1XP_063142844.1  neurabin-1 isoform X6

    RNA

    1. XR_005503322.2 RNA Sequence