U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Akr7a2 aldo-keto reductase family 7, member A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171445, updated on 27-Nov-2024

    Summary

    Official Symbol
    Akr7a2provided by RGD
    Official Full Name
    aldo-keto reductase family 7, member A2provided by RGD
    Primary source
    RGD:620311
    See related
    EnsemblRapid:ENSRNOG00000017780 AllianceGenome:RGD:620311
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aiar
    Summary
    Enables aldose reductase (NADPH) activity. Predicted to be involved in daunorubicin metabolic process and doxorubicin metabolic process. Located in nuclear envelope. Orthologous to human AKR7A2 (aldo-keto reductase family 7 member A2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 1598.8), Liver (RPKM 462.1) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Akr7a2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (156835589..156844127)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151552375..151560914)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157759448..157768473)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487024 Neighboring gene capping actin protein of muscle Z-line subunit beta Neighboring gene solute carrier family 66 member 1 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene ribosomal protein L9, pseudogene 6 Neighboring gene ribosomal protein S21, pseudogene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aldo-keto reductase (NADPH) activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables aldo-keto reductase (NADPH) activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables aldose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phenanthrene-9,10-epoxide hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in daunorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in doxorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    aflatoxin B1 aldehyde reductase member 2
    Names
    SSA reductase
    aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
    rAFAR2
    succinic semialdehyde reductase
    NP_599234.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134407.2NP_599234.1  aflatoxin B1 aldehyde reductase member 2

      See identical proteins and their annotated locations for NP_599234.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q6P765, Q8CG45, Q8K435, Q9JM82
      UniProtKB/TrEMBL
      A0A0G2K3V2, A6ITL3
      Related
      ENSRNOP00000072789.3, ENSRNOT00000083629.3
      Conserved Domains (2) summary
      cd06660
      Location:21325
      Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
      COG0667
      Location:21334
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      156835589..156844127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)