Gcc2 GRIP and coiled-coil domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gcc2provided by MGI
Official Full Name: GRIP and coiled-coil domain containing 2provided by MGI
Primary source: MGI:MGI:1917547
See related: Ensembl:ENSMUSG00000038039 AllianceGenome:MGI:1917547
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0336; 0610043A03Rik; 2210420P05Rik; 2600014C01Rik
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; protein localization to organelle; and retrograde transport, endosome to Golgi. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be active in Golgi apparatus. Orthologous to human GCC2 (GRIP and coiled-coil domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 5.2), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 29.3 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (58091240..58141421)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (58255408..58305599)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW112121 (e-PCR)
- UniSTS:180040

NoName (e-PCR)
- UniSTS:225136

RH118333 (e-PCR)
- UniSTS:160970

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in Golgi ribbon formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in late endosome to Golgi transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in late endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in late endosome to Golgi transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule anchoring	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule organizing center organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule organizing center organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to lysosome	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to lysosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in recycling endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in recycling endosome to Golgi transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein exit from endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein exit from endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: GRIP and coiled-coil domain-containing protein 2

Names: 185 kDa Golgi coiled-coil protein; GCC185

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027375.3 → NP_081651.2 GRIP and coiled-coil domain-containing protein 2

See identical proteins and their annotated locations for NP_081651.2

Status: VALIDATED

Source sequence(s)

AC170751

Consensus CDS

CCDS23859.1

UniProtKB/Swiss-Prot

B2RSU7, Q8BR44, Q8CHG3, Q8R2Q5, Q9CT45

UniProtKB/TrEMBL

E9PWI6

Related

ENSMUSP00000054033.8, ENSMUST00000057659.14

Conserved Domains (4) summary

TIGR02168
Location:624 → 1386

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam01465
Location:1610 → 1652

GRIP; GRIP domain

pfam07851
Location:104 → 203

TMPIT; TMPIT-like protein

pfam16704
Location:1544 → 1608

Rab_bind; Rab binding domain

RNA

NR_176435.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC170751

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

58091240..58141421

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155993.1 → XP_036011886.1 GRIP and coiled-coil domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

E0CYI9

Related

ENSMUSP00000124152.2, ENSMUST00000162860.8

Conserved Domains (4) summary

COG1196
Location:227 → 1044

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:654 → 1370

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam16704
Location:1444 → 1508

Rab_bind; Rab binding domain

pfam01465
Location:1510 → 1552

GRIP; GRIP domain