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    POLR1A RNA polymerase I subunit A [ Homo sapiens (human) ]

    Gene ID: 25885, updated on 10-Dec-2024

    Summary

    Official Symbol
    POLR1Aprovided by HGNC
    Official Full Name
    RNA polymerase I subunit Aprovided by HGNC
    Primary source
    HGNC:HGNC:17264
    See related
    Ensembl:ENSG00000068654 MIM:616404; AllianceGenome:HGNC:17264
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A190; RPA1; HLD27; RPO14; AFDCIN; RPA190; RPA194; RPO1-4
    Summary
    The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016]
    Expression
    Ubiquitous expression in testis (RPKM 5.9), endometrium (RPKM 5.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See POLR1A in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (86020216..86105886, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (86022315..86107956, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (86247339..86333009, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124906031 Neighboring gene uncharacterized LOC105374843 Neighboring gene CRISPRi-validated cis-regulatory element chr2.3134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:86239243-86239743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16150 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:86260844-86261047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11710 Neighboring gene conserved acetylation island sequence 34 enhancer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:86272354-86273553 Neighboring gene MPRA-validated peak3776 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:86296595-86297794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:86301664-86302164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:86302165-86302665 Neighboring gene uncharacterized LOC124907852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16154 Neighboring gene pentatricopeptide repeat domain 3 Neighboring gene Sharpr-MPRA regulatory region 1812 Neighboring gene MPRA-validated peak3777 silencer Neighboring gene small nucleolar RNA, C/D box 94 Neighboring gene inner membrane mitochondrial protein Neighboring gene microRNA 4779

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ10750, FLJ21915, MGC87965, DKFZp586M0122

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding  
    contributes_to DNA-directed 5'-3' RNA polymerase activity  
    enables DNA-directed 5'-3' RNA polymerase activity PubMed 
    enables DNA/RNA hybrid binding PubMed 
    enables RNA polymerase I activity PubMed 
    enables RNA polymerase II activity  
    enables RNA polymerase III activity  
    enables RNA polymerase IV activity  
    enables RNA polymerase V activity  
    enables chromatin binding PubMed 
    enables magnesium ion binding PubMed 
    enables mitochondrial single subunit type RNA polymerase activity  
    enables plastid single subunit type RNA polymerase activity  
    enables protein binding PubMed 
    enables zinc ion binding PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase I complex  
    part_of RNA polymerase I complex PubMed 
    located_in chromosome  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    DNA-directed RNA polymerase I subunit RPA1
    Names
    DNA-directed RNA polymerase I largest subunit
    DNA-directed RNA polymerase I subunit A
    DNA-directed RNA polymerase I subunit A1
    RNA polymerase I 194 kDa subunit
    polymerase (RNA) I polypeptide A, 194kDa
    polymerase (RNA) I subunit A
    NP_056240.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050742.2 RefSeqGene

      Range
      5270..90940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015425.6 → NP_056240.2  DNA-directed RNA polymerase I subunit RPA1

      See identical proteins and their annotated locations for NP_056240.2

      Status: REVIEWED

      Source sequence(s)
      AC012511, AK302458, AK307490, BC073824, BP363163
      Consensus CDS
      CCDS42706.1
      UniProtKB/Swiss-Prot
      B7Z7T0, D6W5M0, O95602, Q0VG05, Q9UEH0, Q9UFT9
      UniProtKB/TrEMBL
      B7ZKR9
      Related
      ENSP00000263857.6, ENST00000263857.11
      Conserved Domains (4) summary
      cd02735
      Location:1199 → 1716
      RNAP_I_Rpa1_C; Largest subunit (Rpa1) of Eukaryotic RNA polymerase I (RNAP I), C-terminal domain
      PRK08566
      Location:4 → 1025
      PRK08566; DNA-directed RNA polymerase subunit A'; Validated
      cd01435
      Location:16 → 1004
      RNAP_I_RPA1_N; Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain
      pfam04998
      Location:958 → 1671
      RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      86020216..86105886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      86022315..86107956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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