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    ZNF223 zinc finger protein 223 [ Homo sapiens (human) ]

    Gene ID: 7766, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF223provided by HGNC
    Official Full Name
    zinc finger protein 223provided by HGNC
    Primary source
    HGNC:HGNC:13016
    See related
    Ensembl:ENSG00000178386 AllianceGenome:HGNC:13016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. The function of this protein has yet to be determined. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.4), urinary bladder (RPKM 1.1) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF223 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44051631..44067999)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46874542..46890907)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44556189..44572152)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF222 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14750 Neighboring gene zinc finger protein 222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44555855-44556356 Neighboring gene zinc finger protein 284 Neighboring gene RNA, U6 small nuclear 902, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14752 Neighboring gene zinc finger protein 224 Neighboring gene ZNF225 and ZNF224 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Coding region intron/exon organization, alternative splicing, and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41. Rosati M, et al. Cytogenet Cell Genet, 1999. PMID 10449920
    2. Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7. Shannon M, et al. Genomics, 1996 Apr 1. PMID 8617494
    3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
    4. A GO catalogue of human DNA-binding transcription factors. Lovering RC, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34673265
    5. The protein interaction landscape of the human CMGC kinase group. Varjosalo M, et al. Cell Rep, 2013 Apr 25. PMID 23602568

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 223
    Names
    Homo sapiens zinc finger protein 223
    KRAB A domain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034021.1 RefSeqGene

      Range
      5026..20989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_013361.6 → NP_037493.3  zinc finger protein 223

      See identical proteins and their annotated locations for NP_037493.3

      Status: VALIDATED

      Source sequence(s)
      AC092072, AF187989, BC022466, DR761157, HY311227
      Consensus CDS
      CCDS12635.1
      UniProtKB/Swiss-Prot
      Q15736, Q8TBJ3, Q9HCA9, Q9UK11
      Related
      ENSP00000401947.1, ENST00000434772.8
      Conserved Domains (6) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:139 → 380
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:346 → 366
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:294 → 310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:218 → 243
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      44051631..44067999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027258.2 → XP_016882747.1  zinc finger protein 223 isoform X1

      UniProtKB/Swiss-Prot
      Q15736, Q8TBJ3, Q9HCA9, Q9UK11
      Conserved Domains (6) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:139 → 380
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:346 → 366
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:294 → 310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:218 → 243
      zf-H2C2_2; Zinc-finger double domain

    2. XM_017027259.2 → XP_016882748.1  zinc finger protein 223 isoform X1

      UniProtKB/Swiss-Prot
      Q15736, Q8TBJ3, Q9HCA9, Q9UK11
      Conserved Domains (6) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:139 → 380
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:346 → 366
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:294 → 310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:218 → 243
      zf-H2C2_2; Zinc-finger double domain

    3. XM_017027260.3 → XP_016882749.1  zinc finger protein 223 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46874542..46890907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322025.1 → XP_054178000.1  zinc finger protein 223 isoform X1

    2. XM_054322024.1 → XP_054177999.1  zinc finger protein 223 isoform X1

    3. XM_054322026.1 → XP_054178001.1  zinc finger protein 223 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UK11.2 GenPept UniProtKB/Swiss-Prot:Q9UK11

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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