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    BCL2L11 BCL2 like 11 [ Sus scrofa (pig) ]

    Gene ID: 396632, updated on 17-Aug-2024

    Summary

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    Official Symbol
    BCL2L11provided by VGNC
    Official Full Name
    BCL2 like 11provided by VGNC
    Primary source
    VGNC:VGNC:97901
    See related
    Ensembl:ENSSSCG00000060053
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    BIMEL
    Expression
    Broad expression in spleen (RPKM 6.9), lung (RPKM 3.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See BCL2L11 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (45156791..45202996, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (47180506..47223992, complement)

    Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106509732 Neighboring gene uncharacterized LOC106509733 Neighboring gene uncharacterized LOC110259966 Neighboring gene uncharacterized LOC110260116 Neighboring gene acyl-CoA oxidase like Neighboring gene two pore calcium channel protein 2-like Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamics and Regulations of BimEL Ser65 and Thr112 Phosphorylation in Porcine Granulosa Cells during Follicular Atresia. Yang F, et al. Cells, 2020 Feb 10. PMID 32050589, Free PMC Article
    2. Melatonin Promotes Ubiquitination of Phosphorylated Pro-Apoptotic Protein Bcl-2-Interacting Mediator of Cell Death-Extra Long (Bim(EL)) in Porcine Granulosa Cells. Wang Y, et al. Int J Mol Sci, 2018 Nov 1. PMID 30388852, Free PMC Article
    3. Oocyte-secreted growth differentiation factor 9 inhibits BCL-2-interacting mediator of cell death-extra long expression in porcine cumulus cell. Wang XL, et al. Biol Reprod, 2013 Sep. PMID 23843241
    4. Follicle-stimulating hormone regulates pro-apoptotic protein Bcl-2-interacting mediator of cell death-extra long (BimEL)-induced porcine granulosa cell apoptosis. Wang XL, et al. J Biol Chem, 2012 Mar 23. PMID 22235114, Free PMC Article
    5. BIM EL-mediated apoptosis in cumulus cells contributes to degenerative changes in aged porcine oocytes via a paracrine action. Wu Y, et al. Theriogenology, 2011 Nov. PMID 21835451

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamics and Regulations of BimEL Ser65 and Thr112 Phosphorylation in Porcine Granulosa Cells during Follicular Atresia.
      Title: Dynamics and Regulations of BimEL Ser65 and Thr112 Phosphorylation in Porcine Granulosa Cells during Follicular Atresia.
    2. melatonin may maintain follicular health by inducing BimEL ubiquitination to inhibit the apoptosis of granulosa cells.
      Title: Melatonin Promotes Ubiquitination of Phosphorylated Pro-Apoptotic Protein Bcl-2-Interacting Mediator of Cell Death-Extra Long (Bim(EL)) in Porcine Granulosa Cells.
    3. Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim.
      Title: Pseudorabies virus glycoprotein gE triggers ERK1/2 phosphorylation and degradation of the pro-apoptotic protein Bim in epithelial cells.
    4. BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9.
      Title: Oocyte-secreted growth differentiation factor 9 inhibits BCL-2-interacting mediator of cell death-extra long expression in porcine cumulus cell.
    5. It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.
      Title: BIM EL-mediated apoptosis in cumulus cells contributes to degenerative changes in aged porcine oocytes via a paracrine action.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in meiosis I IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bcl-2-like protein 11
    Names
    BCL2-like 11 (apoptosis facilitator)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160074.1 → NP_001153546.1  bcl-2-like protein 11 isoform 2

      See identical proteins and their annotated locations for NP_001153546.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      FJ825621
      UniProtKB/TrEMBL
      A0A287AEC6, A0A4X1VRY4, A0A8D0XW56, C1KGB8
      Conserved Domains (2) summary
      pfam06773
      Location:4 → 39
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:43 → 78
      Bclx_interact; Bcl-x interacting, BH3 domain

    2. NM_001252194.1 → NP_001239123.1  bcl-2-like protein 11 isoform 1

      See identical proteins and their annotated locations for NP_001239123.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      FJ825619
      UniProtKB/TrEMBL
      A0A4X1VRX9, A0A4X1VS20, A0A8D0JJW3, A0A8D1NPK5, C1KGB6, I3L699
      Related
      ENSSSCP00000079981.1, ENSSSCT00000105674.1
      Conserved Domains (2) summary
      pfam06773
      Location:4 → 39
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:129 → 164
      Bclx_interact; Bcl-x interacting, BH3 domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

      Range
      45156791..45202996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021085830.1 → XP_020941489.1  bcl-2-like protein 11 isoform X6

      UniProtKB/TrEMBL
      A0A4X1VRX9, A0A4X1VSJ0, A0A8D0JJW3, A0A8D0TJB8, A0A8W4FNQ6, I3L699
      Related
      ENSSSCP00000080995.1, ENSSSCT00000097233.1
      Conserved Domains (2) summary
      pfam06773
      Location:4 → 39
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:128 → 161
      Bclx_interact; Bcl-x interacting, BH3 domain

    2. XM_021085826.1 → XP_020941485.1  bcl-2-like protein 11 isoform X2

      Conserved Domains (3) summary
      pfam06773
      Location:97 → 132
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:165 → 198
      Bclx_interact; Bcl-x interacting, BH3 domain
      cl02575
      Location:134 → 203
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

    3. XM_021085828.1 → XP_020941487.1  bcl-2-like protein 11 isoform X4

      Conserved Domains (1) summary
      pfam06773
      Location:97 → 132
      Bim_N; Bim protein N-terminus

    4. XM_021085829.1 → XP_020941488.1  bcl-2-like protein 11 isoform X5

      Conserved Domains (2) summary
      pfam06773
      Location:97 → 132
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:135 → 168
      Bclx_interact; Bcl-x interacting, BH3 domain

    5. XM_021085825.1 → XP_020941484.1  bcl-2-like protein 11 isoform X1

      UniProtKB/TrEMBL
      A0A8D1A276
      Conserved Domains (2) summary
      pfam06773
      Location:97 → 132
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:221 → 254
      Bclx_interact; Bcl-x interacting, BH3 domain

    6. XM_021085832.1 → XP_020941491.1  bcl-2-like protein 11 isoform X7

      Conserved Domains (1) summary
      pfam06773
      Location:97 → 132
      Bim_N; Bim protein N-terminus

    7. XM_021085827.1 → XP_020941486.1  bcl-2-like protein 11 isoform X3

      Conserved Domains (1) summary
      pfam06773
      Location:97 → 132
      Bim_N; Bim protein N-terminus

    RNA

    1. XR_002342159.1 RNA Sequence

    2. XR_002342157.1 RNA Sequence

    3. XR_002342158.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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