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    Ppp2r1b protein phosphatase 2, regulatory subunit A, beta [ Mus musculus (house mouse) ]

    Gene ID: 73699, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppp2r1bprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit A, betaprovided by MGI
    Primary source
    MGI:MGI:1920949
    See related
    Ensembl:ENSMUSG00000032058 AllianceGenome:MGI:1920949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410091N08Rik
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in apoptotic process involved in morphogenesis; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and protein dephosphorylation. Is active in glutamatergic synapse. Is expressed in several structures, including cerebral cortex; eye; genitourinary system; thymus primordium; and tooth. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human PPP2R1B (protein phosphatase 2 scaffold subunit Abeta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 19.8), genital fat pad adult (RPKM 16.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp2r1b in Genome Data Viewer
    Location:
    9 A5.3; 9 27.75 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50767946..50810625)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50856896..50899325)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3828 Neighboring gene STARR-positive B cell enhancer ABC_E9760 Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene predicted gene, 57547 Neighboring gene STARR-seq mESC enhancer starr_24122 Neighboring gene STARR-positive B cell enhancer mm9_chr9:50664895-50665195 Neighboring gene predicted gene, 25558 Neighboring gene salt inducible kinase 2 Neighboring gene STARR-seq mESC enhancer starr_24123 Neighboring gene STARR-seq mESC enhancer starr_24124 Neighboring gene STARR-positive B cell enhancer ABC_E8290 Neighboring gene predicted gene, 32681 Neighboring gene layilin Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34c Neighboring gene BTG anti-proliferation factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The PP2A-Aβ gene is regulated by multiple transcriptional factors including Ets-1, SP1/SP3, and RXRα/β. Liu J, et al. Curr Mol Med, 2012 Sep. PMID 22827437
    2. PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis. Du M, et al. FASEB J, 2021 May. PMID 33913576
    3. A Chromatin Accessibility Atlas of the Developing Human Telencephalon. Markenscoff-Papadimitriou E, et al. Cell, 2020 Aug 6. PMID 32610082, Free PMC Article
    4. Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye. Liu WB, et al. Mol Vis, 2008 Apr 21. PMID 18432318, Free PMC Article
    5. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Guenebeaud C, et al. Mol Cell, 2010 Dec 22. PMID 21172653

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis.
      Title: PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis.
    2. Multiple transcription factors regulate the PP2A-Abeta gene.
      Title: The PP2A-Aβ gene is regulated by multiple transcriptional factors including Ets-1, SP1/SP3, and RXRα/β.
    3. PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
      Title: Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process involved in morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic sister chromatid cohesion, centromeric IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
    NP_001029257.1
    NP_001273482.1
    NP_082890.2
    XP_006510704.3
    XP_006510705.3
    XP_036011230.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034085.2 → NP_001029257.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a

      See identical proteins and their annotated locations for NP_001029257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 3. It encodes isoform a, which has a shorter and distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AC123614, AK161392
      Consensus CDS
      CCDS40625.1
      UniProtKB/TrEMBL
      H3BKU1, Q3TTF6
      Related
      ENSMUSP00000034560.8, ENSMUST00000034560.14
      Conserved Domains (2) summary
      COG1413
      Location:227 → 474
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:257 → 281
      HEAT; HEAT repeat [structural motif]

    2. NM_001286553.1 → NP_001273482.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (c).
      Source sequence(s)
      AC123614, AK077158, AK136106, AK161392
      Consensus CDS
      CCDS72232.1
      UniProtKB/TrEMBL
      G3UWS4, Q8BIX1
      Related
      ENSMUSP00000133404.2, ENSMUST00000174628.8
      Conserved Domains (4) summary
      pfam02985
      Location:295 → 325
      HEAT; HEAT repeat
      pfam13513
      Location:191 → 240
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:217 → 315
      HEAT_2; HEAT repeats
      sd00044
      Location:257 → 281
      HEAT; HEAT repeat [structural motif]

    3. NM_028614.3 → NP_082890.2  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b

      See identical proteins and their annotated locations for NP_082890.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' structure and contains a 3' terminal exon which extends past a splice site that is used in variant 3. It encodes isoform b, which has a shorter and distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AC123614, AK010754, AK077158, AK136106, BC056218, BM932667, BY687256, CX566645
      Consensus CDS
      CCDS40626.1
      UniProtKB/Swiss-Prot
      E9QNJ1, Q7TNP2
      UniProtKB/TrEMBL
      H3BKU1
      Related
      ENSMUSP00000110080.3, ENSMUST00000114437.9
      Conserved Domains (2) summary
      sd00044
      Location:257 → 281
      HEAT; HEAT repeat [structural motif]
      cl26104
      Location:227 → 474
      HEAT_2; HEAT repeats

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      50767946..50810625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510641.5 → XP_006510704.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

      UniProtKB/TrEMBL
      H3BKU1
      Related
      ENSMUSP00000135525.2, ENSMUST00000176798.8
      Conserved Domains (3) summary
      COG1413
      Location:325 → 572
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:355 → 379
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:276 → 306
      HEAT; HEAT repeat

    2. XM_006510642.5 → XP_006510705.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

      UniProtKB/TrEMBL
      H3BKU1
      Conserved Domains (3) summary
      COG1413
      Location:325 → 572
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:355 → 379
      HEAT; HEAT repeat [structural motif]
      pfam02985
      Location:276 → 306
      HEAT; HEAT repeat

    3. XM_036155337.1 → XP_036011230.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3

      UniProtKB/TrEMBL
      H3BIV7
      Conserved Domains (2) summary
      COG1413
      Location:2 → 246
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:66 → 90
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_001779023.3 RNA Sequence

    2. XR_001779024.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNP2.2 GenPept UniProtKB/Swiss-Prot:Q7TNP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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