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    Rdh7 retinol dehydrogenase 7 [ Mus musculus (house mouse) ]

    Gene ID: 54150, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rdh7provided by MGI
    Official Full Name
    retinol dehydrogenase 7provided by MGI
    Primary source
    MGI:MGI:1860517
    See related
    Ensembl:ENSMUSG00000040134 AllianceGenome:MGI:1860517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRAD2
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity; androstan-3-alpha,17-beta-diol dehydrogenase activity; and androsterone dehydrogenase activity. Predicted to be involved in retinol metabolic process and steroid metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in alimentary system; intestine; liver; metanephros; and stomach. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 592.0) and liver E18 (RPKM 146.7) See more
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    Genomic context

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    See Rdh7 in Genome Data Viewer
    Location:
    10 D3; 10 76.39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127719896..127725116, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127884027..127889247, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 19 Neighboring gene RDH16 family member 2 Neighboring gene predicted gene, 31091 Neighboring gene STARR-seq mESC enhancer starr_28247 Neighboring gene STARR-seq mESC enhancer starr_28249 Neighboring gene 4short chain dehydrogenase/reductase family 9C, member 7 Neighboring gene STARR-seq mESC enhancer starr_28250 Neighboring gene predicted gene, 40804

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene structure and promoter for Crad2 encoding mouse cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme. Tomita K, et al. Gene, 2000 Jun 27. PMID 10876094
    2. cDNA cloning, tissue distribution, and substrate characteristics of a cis-Retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme. Su J, et al. J Biol Chem, 1998 Jul 10. PMID 9651397
    3. Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis. Grizotte-Lake M, et al. Immunity, 2018 Dec 18. PMID 30566883, Free PMC Article
    4. Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally. Ulven SM, et al. Dev Dyn, 2001 Nov. PMID 11747070
    5. Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid. Ulven SM, et al. Dev Biol, 2000 Apr 15. PMID 10753524

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    retinol dehydrogenase 7
    Names
    CRAD-2
    cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2
    cis-retinol/androgen dehydrogenase type 2
    NP_001144221.1
    NP_059501.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001150749.1 → NP_001144221.1  retinol dehydrogenase 7

      See identical proteins and their annotated locations for NP_001144221.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB015165, AI255893, CB951082, CJ097101
      Consensus CDS
      CCDS24255.1
      UniProtKB/Swiss-Prot
      O88451
      Related
      ENSMUSP00000039252.5, ENSMUST00000047199.5
      Conserved Domains (2) summary
      cd09805
      Location:30 → 305
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
      pfam00106
      Location:30 → 217
      adh_short; short chain dehydrogenase

    2. NM_017473.4 → NP_059501.1  retinol dehydrogenase 7

      See identical proteins and their annotated locations for NP_059501.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA260496, AC131690, AF056194
      Consensus CDS
      CCDS24255.1
      UniProtKB/Swiss-Prot
      O88451
      Conserved Domains (2) summary
      cd09805
      Location:30 → 305
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
      pfam00106
      Location:30 → 217
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127719896..127725116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88451.1 GenPept UniProtKB/Swiss-Prot:O88451

    Gene LinkOut

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