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    Syce1l synaptonemal complex central element protein 1 like [ Mus musculus (house mouse) ]

    Gene ID: 668110, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Syce1lprovided by MGI
    Official Full Name
    synaptonemal complex central element protein 1 likeprovided by MGI
    Primary source
    MGI:MGI:1922247
    See related
    Ensembl:ENSMUSG00000033409 AllianceGenome:MGI:1922247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MMRP; PSESS; mmrp2; 4930481F22Rik
    Summary
    Predicted to be involved in synaptonemal complex assembly. Predicted to be located in intermediate filament cytoskeleton. Predicted to be active in synaptonemal complex. Is expressed in colon; metanephros; spleen; submandibular gland; and testis. Orthologous to human SYCE1L (synaptonemal complex central element protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 10.9), thymus adult (RPKM 8.5) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Syce1l in Genome Data Viewer
    Location:
    8 E1; 8 59.65 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (114369845..114382165)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (113643213..113655533)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930571O06 gene Neighboring gene predicted gene, 24291 Neighboring gene STARR-seq mESC enhancer starr_22761 Neighboring gene collagen, type III, alpha 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22762 Neighboring gene STARR-positive B cell enhancer ABC_E1771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:116159691-116159874 Neighboring gene MON1 homolog B, secretory traffciking associated Neighboring gene predicted gene, 30052 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a new transcript specifically expressed in mouse spermatocytes: mmrp2. Gu S, et al. Mol Biol Rep, 2005 Dec. PMID 16328886
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in synaptonemal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptonemal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptonemal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    synaptonemal complex central element protein 1-like
    Names
    meiosis-related protein
    predicted second spermatocyte specific protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048145.1 → NP_001041610.1  synaptonemal complex central element protein 1-like isoform 1

      See identical proteins and their annotated locations for NP_001041610.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC125463, BB616021
      Consensus CDS
      CCDS40483.1
      UniProtKB/Swiss-Prot
      B2RUQ1, Q497L4, Q5D524, Q5D525, Q9D5A5
      Related
      ENSMUSP00000092796.2, ENSMUST00000095173.3
      Conserved Domains (1) summary
      pfam15233
      Location:50 → 172
      SYCE1; Synaptonemal complex central element protein 1

    2. NM_001286494.1 → NP_001273423.1  synaptonemal complex central element protein 1-like isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AK015606, BC100478, BC141326
      Consensus CDS
      CCDS85617.1
      UniProtKB/Swiss-Prot
      Q5D525
      Related
      ENSMUSP00000148356.2, ENSMUST00000212269.2
      Conserved Domains (1) summary
      pfam15233
      Location:29 → 151
      SYCE1; Synaptonemal complex central element protein 1

    3. NM_029139.1 → NP_083415.1  synaptonemal complex central element protein 1-like isoform 2

      See identical proteins and their annotated locations for NP_083415.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon, which results in a frameshift, compared to variant 1. This encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC125463, AK015606
      Consensus CDS
      CCDS40484.1
      UniProtKB/Swiss-Prot
      Q5D525
      Related
      ENSMUSP00000034219.5, ENSMUST00000034219.12
      Conserved Domains (1) summary
      pfam15233
      Location:50 → 130
      SYCE1; Synaptonemal complex central element protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      114369845..114382165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5D525.2 GenPept UniProtKB/Swiss-Prot:Q5D525

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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