U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DRD5 dopamine receptor D5 [ Homo sapiens (human) ]

    Gene ID: 1816, updated on 9-Dec-2024

    Summary

    Official Symbol
    DRD5provided by HGNC
    Official Full Name
    dopamine receptor D5provided by HGNC
    Primary source
    HGNC:HGNC:3026
    See related
    Ensembl:ENSG00000169676 MIM:126453; AllianceGenome:HGNC:3026
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DBDR; DRD1B; DRD1L2
    Summary
    This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DRD5 in Genome Data Viewer
    Location:
    4p16.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (9781634..9784009)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (9781407..9783782)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (9783258..9785633)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene EVA1C pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15273 Neighboring gene olfactory receptor family 7 subfamily E member 35 pseudogene Neighboring gene solute carrier family 2 member 9 Neighboring gene RNA, 5S ribosomal pseudogene 154 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:9945957-9947156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21303 Neighboring gene SLC2A9 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21304

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Blepharospasm, benign essential, susceptibility to
    MedGen: C4692845 OMIM: 606798 GeneReviews: Not available
    not available
    Hereditary attention deficit-hyperactivity disorder
    MedGen: CN324066 OMIM: 143465 GeneReviews: Not available
    not available

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-05-15)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-05-15)

    ClinGen Genome Curation Page

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC10601

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dopamine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dopamine neurotransmitter receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dopamine neurotransmitter receptor activity, coupled via Gs IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dopamine neurotransmitter receptor activity, coupled via Gs TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating dopamine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to catecholamine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chemical synaptic transmission NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intracellular calcium ion homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in long-term synaptic depression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of NAD(P)H oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating dopamine receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of adenylate cyclase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of female receptivity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of systemic arterial blood pressure by vasopressin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensitization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, dopaminergic NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    D(1B) dopamine receptor
    Names
    D1beta dopamine receptor
    d(5) dopamine receptor
    dopamine D5 receptor
    dopamine receptor D1B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012024.1 RefSeqGene

      Range
      5001..7376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000798.5NP_000789.1  D(1B) dopamine receptor

      See identical proteins and their annotated locations for NP_000789.1

      Status: REVIEWED

      Source sequence(s)
      AC098976, BC009748
      Consensus CDS
      CCDS3405.1
      UniProtKB/Swiss-Prot
      B2R9S3, P21918, Q8NEQ8
      Related
      ENSP00000306129.2, ENST00000304374.4
      Conserved Domains (2) summary
      pfam00001
      Location:57359
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:123175
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      9781634..9784009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      9781407..9783782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)