U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tspo2 translocator protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 70026, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tspo2provided by MGI
    Official Full Name
    translocator protein 2provided by MGI
    Primary source
    MGI:MGI:1917276
    See related
    Ensembl:ENSMUSG00000023995 AllianceGenome:MGI:1917276
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bzrpl1; 2510027D20Rik
    Summary
    Enables cholesterol binding activity. Involved in enucleate erythrocyte differentiation; intracellular cholesterol transport; and lipid droplet organization. Located in endoplasmic reticulum. Is expressed in several structures, including jaw; liver; skeleton; and spleen. Orthologous to human TSPO2 (translocator protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14.5 (RPKM 59.7), liver E14 (RPKM 47.7) and 2 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tspo2 in Genome Data Viewer
    Location:
    17 C; 17 24.12 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48754970..48758592, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48447942..48451564, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48549466-48549575 Neighboring gene STARR-positive B cell enhancer ABC_E7541 Neighboring gene STARR-seq mESC enhancer starr_42751 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48567545-48567654 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 Neighboring gene predicted gene, 30283 Neighboring gene VISTA enhancer mm243 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48601436-48601659 Neighboring gene unc-5 family C-terminal like Neighboring gene STARR-seq mESC enhancer starr_42753 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48649023-48649224 Neighboring gene predicted gene, 30419

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. Kiatpakdee B, et al. J Biol Chem, 2020 Jun 5. PMID 32358067, Free PMC Article
    2. Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis. Fan J, et al. J Biol Chem, 2009 Oct 30. PMID 19729679, Free PMC Article
    3. Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis. Huang S, et al. Nat Commun, 2024 Aug 15. PMID 39147774, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts.
      Title: Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts.
    2. identify the TSPO2 family of proteins as mediators of cholesterol redistribution-dependent erythroblast maturation during mammalian erythropoiesis
      Title: Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC129410, MGC129411

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5-aminolevulinic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5-aminolevulinic acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cholesterol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 5-aminolevulinic acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 5-aminolevulinic acid import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in enucleate erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid droplet organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    translocator protein 2
    Names
    benzodiazapine receptor, peripheral-like 1
    peripheral-type benzodiazepine receptor-like protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027292.2 → NP_081568.1  translocator protein 2

      See identical proteins and their annotated locations for NP_081568.1

      Status: PROVISIONAL

      Source sequence(s)
      AK011003
      Consensus CDS
      CCDS28869.1
      UniProtKB/Swiss-Prot
      Q9CRZ8
      UniProtKB/TrEMBL
      E0CX84
      Related
      ENSMUSP00000024794.6, ENSMUST00000024794.12
      Conserved Domains (1) summary
      pfam03073
      Location:10 → 153
      TspO_MBR; TspO/MBR family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48754970..48758592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317631.2 → XP_017173120.1  translocator protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9CRZ8
      UniProtKB/TrEMBL
      E0CX84
      Conserved Domains (1) summary
      pfam03073
      Location:10 → 153
      TspO_MBR; TspO/MBR family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRZ8.2 GenPept UniProtKB/Swiss-Prot:Q9CRZ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools