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    Cend1 cell cycle exit and neuronal differentiation 1 [ Mus musculus (house mouse) ]

    Gene ID: 57754, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cend1provided by MGI
    Official Full Name
    cell cycle exit and neuronal differentiation 1provided by MGI
    Primary source
    MGI:MGI:1929898
    See related
    Ensembl:ENSMUSG00000060240 AllianceGenome:MGI:1929898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BM88; 1500001H12Rik
    Summary
    Involved in neuron differentiation. Acts upstream of or within adult walking behavior; hindbrain development; and negative regulation of cerebellar granule cell precursor proliferation. Predicted to be located in membrane. Predicted to colocalize with mitochondrion and vesicle. Is expressed in central nervous system; peripheral nervous system ganglion; sensory organ; and urethra. Orthologous to human CEND1 (cell cycle exit and neuronal differentiation 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 92.4), cortex adult (RPKM 51.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cend1 in Genome Data Viewer
    Location:
    7 F5; 7 86.77 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141006359..141009475, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141426446..141429562, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene glutamine amidotransferase like class 1 domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3761 Neighboring gene solute carrier family 25 (mitochondrial carrier, glutamate), member 22 Neighboring gene STARR-positive B cell enhancer ABC_E4986 Neighboring gene p53 induced death domain protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1097

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BM88/CEND1 coordinates cell cycle exit and differentiation of neuronal precursors. Politis PK, et al. Proc Natl Acad Sci U S A, 2007 Nov 6. PMID 17971443, Free PMC Article
    2. CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease. Xie W, et al. Cell Death Differ, 2022 Dec. PMID 35732922, Free PMC Article
    3. Increased Anxiety-Related Behavior, Impaired Cognitive Function and Cellular Alterations in the Brain of Cend1-deficient Mice. Segklia K, et al. Front Cell Neurosci, 2018. PMID 30760981, Free PMC Article
    4. CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons. Aravantinou-Fatorou K, et al. Stem Cell Reports, 2015 Sep 8. PMID 26321141, Free PMC Article
    5. BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells. Katsimpardi L, et al. Stem Cells, 2008 Jul. PMID 18499894

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease.
      Title: CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease.
    2. data suggest that common reprogramming mechanisms exist driving the conversion of lineage-distant somatic cell types to neurons and reveal a critical role for CEND1 in NEUROG2-driven astrocytic reprogramming.
      Title: CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons.
    3. results suggest that functional interactions between BM88/Cend1, RanBPM and Dyrk1B affect the balance between cellular proliferation and differentiation in Neuro 2a cells
      Title: Functional Interactions between BM88/Cend1, Ran-binding protein M and Dyrk1B kinase affect cyclin D1 levels and cell cycle progression/exit in mouse neuroblastoma cells.
    4. This study suggested that Cend1 is involved in Ahi1-associated hypothalamic neuronal differentiation in early development, giving us fresh insight into the mechanism behind the delayed development in Joubert syndrome.
      Title: Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.
    5. Our results suggest that Cend1 is required for normal cerebellar development.
      Title: Impaired cerebellar development and deficits in motor coordination in mice lacking the neuronal protein BM88/Cend1.
    6. Transplantation of BM88/Cend1-overexpressing neural progenitor cells exerts beneficial effects on tissue regeneration by enhancing the number of generated neurons and restricting the formation of astroglial scar, in a mouse model of cortical brain injury.
      Title: Transplantation of embryonic neural stem/precursor cells overexpressing BM88/Cend1 enhances the generation of neuronal cells in the injured mouse cortex.
    7. BM88/Cend1 participates in cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis and becomes crucial for the transition from neuroblasts to mature neurons when reaching high levels
      Title: BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells.
    8. Results implicate BM88 in the synchronization of cell cycle exit and differentiation of neuronal precursors in the developing nervous system.
      Title: BM88/CEND1 coordinates cell cycle exit and differentiation of neuronal precursors.
    9. BM88 is widely expressed in the embryonic CNS and PNS, in both nestin-positive neuroepithelial cells and post-mitotic betaIII-tubulin positive neurons.
      Title: Expression pattern of BM88 in the developing nervous system of the chick and mouse embryo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cerebellar Purkinje cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cerebellar Purkinje cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cerebellar granular layer maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cerebellar granular layer maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cerebellar granule cell precursor proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in radial glia guided migration of cerebellar granule cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within radial glia guided migration of cerebellar granule cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell cycle exit and neuronal differentiation protein 1
    Names
    BM88 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360485.1 → NP_001347414.1  cell cycle exit and neuronal differentiation protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC158224, AC163434
      Consensus CDS
      CCDS22012.1
      UniProtKB/Swiss-Prot
      Q9DBA0, Q9JKC6
      Related
      ENSMUSP00000123334.2, ENSMUST00000137488.2
      Conserved Domains (1) summary
      pfam15677
      Location:1 → 149
      CEND1; Cell cycle exit and neuronal differentiation protein 1

    2. NM_021316.5 → NP_067291.1  cell cycle exit and neuronal differentiation protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC158224, AC163434, AK079045
      Consensus CDS
      CCDS22012.1
      UniProtKB/Swiss-Prot
      Q9DBA0, Q9JKC6
      Related
      ENSMUSP00000118591.2, ENSMUST00000124444.2
      Conserved Domains (1) summary
      pfam15677
      Location:1 → 149
      CEND1; Cell cycle exit and neuronal differentiation protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141006359..141009475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKC6.1 GenPept UniProtKB/Swiss-Prot:Q9JKC6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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