Fut2 fucosyltransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fut2provided by MGI
Official Full Name: fucosyltransferase 2provided by MGI
Primary source: MGI:MGI:109374
See related: Ensembl:ENSMUSG00000055978 AllianceGenome:MGI:109374
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MFUT-II
Summary: This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression: Biased expression in colon adult (RPKM 53.5), stomach adult (RPKM 21.9) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.41 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (45298015..45315818, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45648591..45666394, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fut2 deficiency aggravates chronic colitis through 2-oxindole-AHR mediated cGAS-STING pathway.
Title: Fut2 deficiency aggravates chronic colitis through 2-oxindole-AHR mediated cGAS-STING pathway.
FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation.
Title: FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation.
FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
Title: FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
Title: Intestinal epithelium-specific Fut2 deficiency promotes colorectal cancer through down-regulating fucosylation of MCAM.
Intestinal commensal microbiota and cytokines regulate Fut2(+) Paneth cells for gut defense.
Title: Intestinal commensal microbiota and cytokines regulate Fut2(+) Paneth cells for gut defense.
Deficiency of Intestinal alpha1-2-Fucosylation Exacerbates Ethanol-Induced Liver Disease in Mice.
Title: Deficiency of Intestinal α1-2-Fucosylation Exacerbates Ethanol-Induced Liver Disease in Mice.
Mice lacking fucosyltransferase 2 show reduced innate allergic inflammation in the airways.
Title: Mice lacking fucosyltransferase 2 show reduced innate allergic inflammation in the airways.
Our data suggest that Fut2 plays a key role in immune responses in the lung and could be a novel therapeutic target of asthma.
Title: Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation.
Results indicate that the fucosyltransferase 2 (FUT2) determines the O-glycosylation pattern of mucin-5AC (Muc5ac).
Title: Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding.
Fut2 gene expression is responsible for disease progression in mice with primary sclerosing cholangitis.
Title: Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-(1,2)-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-(1,2)-fucosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha-(1,2)-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactoside 2-alpha-L-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactoside 2-alpha-L-fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactoside 2-alpha-L-fucosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables galactoside 2-alpha-L-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fucosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in fucosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fucosylation	ISO Inferred from Sequence Orthology more info
involved_in glycolipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligosaccharide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galactoside alpha-(1,2)-fucosyltransferase 2

Names: GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase; alpha(1,2)FT 2; galactoside 2-alpha-L-fucosyltransferase 2; secretory blood group protein 2; type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2; type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2

NP_001258922.1

EC 2.4.1.344

EC 2.4.1.69

NP_061364.2

EC 2.4.1.344

EC 2.4.1.69

XP_011249097.1

EC 2.4.1.344

EC 2.4.1.69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271993.1 → NP_001258922.1 galactoside alpha-(1,2)-fucosyltransferase 2

See identical proteins and their annotated locations for NP_001258922.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK033520, AK033586, BC145831, BQ032725, BY142283

Consensus CDS

CCDS21258.1

UniProtKB/Swiss-Prot

O70504, Q9JL27

UniProtKB/TrEMBL

A6H6C9, Q91VF0

Conserved Domains (1) summary

pfam01531
Location:59 → 337

Glyco_transf_11; Glycosyl transferase family 11
NM_018876.4 → NP_061364.2 galactoside alpha-(1,2)-fucosyltransferase 2

See identical proteins and their annotated locations for NP_061364.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK033520, AK033586, BC145831, BQ032725

Consensus CDS

CCDS21258.1

UniProtKB/Swiss-Prot

O70504, Q9JL27

UniProtKB/TrEMBL

A6H6C9, Q91VF0

Related

ENSMUSP00000063719.5, ENSMUST00000069800.6

Conserved Domains (1) summary

pfam01531
Location:59 → 337

Glyco_transf_11; Glycosyl transferase family 11