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    Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 [ Mus musculus (house mouse) ]

    Gene ID: 114664, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hsd17b11provided by MGI
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 11provided by MGI
    Primary source
    MGI:MGI:2149821
    See related
    Ensembl:ENSMUSG00000029311 AllianceGenome:MGI:2149821
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SDR2; Dhrs8; Pan1b; retSDR2
    Summary
    Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Predicted to be involved in androgen catabolic process. Predicted to be located in cytoplasm. Predicted to be active in lipid droplet. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver; and sensory organ. Orthologous to human HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 49.0), duodenum adult (RPKM 48.7) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Hsd17b11 in Genome Data Viewer
    Location:
    5 E5; 5 50.52 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (104137631..104169662, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (103989765..104021796, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene kelch-like 8 Neighboring gene predicted gene, 24897 Neighboring gene STARR-positive B cell enhancer mm9_chr5:104356466-104356766 Neighboring gene STARR-seq mESC enhancer starr_13815 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:104436899-104437123 Neighboring gene STARR-seq mESC enhancer starr_13817 Neighboring gene STARR-seq mESC enhancer starr_13818 Neighboring gene STARR-positive B cell enhancer ABC_E2165 Neighboring gene microRNA 5619 Neighboring gene predicted gene, 52783 Neighboring gene nudix hydrolase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables steroid dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables steroid dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in androgen catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in androgen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    estradiol 17-beta-dehydrogenase 11
    Names
    17-beta-HSD 11
    17-beta-HSD XI
    17-beta-hydroxysteroid dehydrogenase 11
    17-beta-hydroxysteroid dehydrogenase XI
    17bHSD11
    17beta-HSD11
    17betaHSD11
    17betaHSDXI
    dehydrogenase/reductase (SDR family) member 8
    retinal short-chain dehydrogenase/reductase 2
    retinal short-chain dehydrogenase/reductase SDR2
    NP_444492.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053262.3NP_444492.1  estradiol 17-beta-dehydrogenase 11 precursor

      Status: PROVISIONAL

      Source sequence(s)
      AL714024
      Consensus CDS
      CCDS19481.1
      UniProtKB/Swiss-Prot
      Q3U2P6, Q8BR33, Q8C7S0, Q9EQ06
      Related
      ENSMUSP00000031251.10, ENSMUST00000031251.16
      Conserved Domains (2) summary
      cd05339
      Location:38277
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      pfam00106
      Location:37228
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      104137631..104169662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)