Znrf2 zinc and ring finger 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Znrf2provided by MGI
Official Full Name: zinc and ring finger 2provided by MGI
Primary source: MGI:MGI:1196246
See related: Ensembl:ENSMUSG00000058446 AllianceGenome:MGI:1196246
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D6Ertd365e; 1190002C14Rik
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Predicted to be located in cytoplasmic vesicle membrane; nuclear lumen; and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Is expressed in cerebral cortex mantle layer; cortical plate; cortical subplate; and olfactory cortex mantle layer. Orthologous to human ZNRF2 (zinc and ring finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 22.8), ovary adult (RPKM 17.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.15 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (54793901..54867209)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (54816916..54890224)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

AU044205 (e-PCR)
- UniSTS:159510

RH127066 (e-PCR)
- UniSTS:167481

NoName (e-PCR)
- UniSTS:485251

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of autophagosome-lysosome fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome-lysosome fusion	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K48-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase ZNRF2

Names: RING-type E3 ubiquitin transferase ZNRF2; zinc finger/RING finger 2; zinc/RING finger protein 2

NP_954594.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199143.2 → NP_954594.1 E3 ubiquitin-protein ligase ZNRF2

Status: VALIDATED

Source sequence(s)

AC079183, AF513708, AK078666

Consensus CDS

CCDS20159.1

UniProtKB/Swiss-Prot

Q71FD5

Related

ENSMUSP00000078795.7, ENSMUST00000079869.13

Conserved Domains (1) summary

pfam13639
Location:193 → 233

zf-RING_2; Ring finger domain