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    Kras Kirsten rat sarcoma viral oncogene homolog [ Mus musculus (house mouse) ]

    Gene ID: 16653, updated on 3-Dec-2024

    Summary

    Official Symbol
    Krasprovided by MGI
    Official Full Name
    Kirsten rat sarcoma viral oncogene homologprovided by MGI
    Primary source
    MGI:MGI:96680
    See related
    Ensembl:ENSMUSG00000030265 AllianceGenome:MGI:96680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras
    Summary
    Enables GTPase activity and protein-membrane adaptor activity. Acts upstream of or within several processes, including Ras protein signal transduction; forebrain astrocyte development; and modulation of chemical synaptic transmission. Located in membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and limb. Used to study several diseases, including Noonan syndrome 3; arteriovenous malformations of the brain; gastrointestinal system cancer (multiple); pancreatic carcinoma (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 17.0), whole brain E14.5 (RPKM 16.2) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kras in Genome Data Viewer
    Location:
    6 G3; 6 77.37 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145162425..145197631, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145216699..145250420, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2809 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145072197-145072498 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4880 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene predicted gene 15543 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene STARR-seq mESC enhancer starr_17780 Neighboring gene predicted gene 15706 Neighboring gene ribosomal protein S25, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_17782 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:145252111-145252451 Neighboring gene lactate dehydrogenase A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC7141

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables LRR domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein-membrane adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of Rac protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within forebrain astrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of glial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of Rac protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of glial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within striated muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of type I pneumocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within visual learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    GTPase KRas
    Names
    Kirsten rat sarcoma oncogene 2, expressed
    p21 protein
    v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
    NP_001390169.1
    NP_001390170.1
    NP_001390171.1
    NP_001390172.1
    NP_001390173.1
    NP_001390174.1
    NP_001390175.1
    NP_067259.4
    XP_006506982.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403240.1NP_001390169.1  GTPase KRas isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157091
      UniProtKB/TrEMBL
      Q3U2W7, Q5J7N1
    2. NM_001403241.1NP_001390170.1  GTPase KRas isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157091
      UniProtKB/TrEMBL
      Q3U2W7, Q5J7N1
    3. NM_001403242.1NP_001390171.1  GTPase KRas isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157091
      UniProtKB/TrEMBL
      Q3U2W7, Q5J7N1
    4. NM_001403243.1NP_001390172.1  GTPase KRas isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157091
      UniProtKB/Swiss-Prot
      P04200, P08643, P32883
      UniProtKB/TrEMBL
      A0A0G2JGP4, Q0VDV7
      Related
      ENSMUSP00000107339.2, ENSMUST00000111710.8
    5. NM_001403244.1NP_001390173.1  GTPase KRas isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157091
    6. NM_001403245.1NP_001390174.1  GTPase KRas isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157091
    7. NM_001403246.1NP_001390175.1  GTPase KRas isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157091
      UniProtKB/TrEMBL
      A0A0N4SVY1
      Related
      ENSMUSP00000145294.2, ENSMUST00000203147.3
    8. NM_021284.7NP_067259.4  GTPase KRas isoform 1

      See identical proteins and their annotated locations for NP_067259.4

      Status: VALIDATED

      Source sequence(s)
      AC157091
      Consensus CDS
      CCDS20693.1
      UniProtKB/TrEMBL
      Q3U2W7, Q5J7N1
      Related
      ENSMUSP00000032399.6, ENSMUST00000032399.12
      Conserved Domains (2) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
      smart00010
      Location:16166
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

    RNA

    1. NR_175367.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157091
    2. NR_175368.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157091

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      145162425..145197631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506919.5XP_006506982.1  GTPase KRas isoform X2

      See identical proteins and their annotated locations for XP_006506982.1

      UniProtKB/TrEMBL
      Q3U2W7
      Conserved Domains (1) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B