Rap1gds1 RAP1, GTP-GDP dissociation stimulator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rap1gds1provided by MGI
Official Full Name: RAP1, GTP-GDP dissociation stimulator 1provided by MGI
Primary source: MGI:MGI:2385189
See related: Ensembl:ENSMUSG00000028149 AllianceGenome:MGI:2385189
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GDS1
Summary: Enables GTPase regulator activity. Acts upstream of or within several processes, including angiotensin-activated signaling pathway involved in heart process; negative regulation of GTPase activity; and regulation of matrix metallopeptidase secretion. Located in extracellular space. Is expressed in several structures, including central nervous system; glans of male genital tubercle; lens; liver; and retina nuclear layer. Orthologous to human RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 49.1), cortex adult (RPKM 47.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H1; 3 64.52 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (138631662..138781163, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (138925897..139075228, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vimar/RAP1GDS1 promotes acceleration of brain aging after flies and mice reach middle age.
Title: Vimar/RAP1GDS1 promotes acceleration of brain aging after flies and mice reach middle age.
Apoe(-/-) SmgGDS(+/-) mice showed significantly higher levels of oxidative stress, matrix metalloproteinases, and inflammatory cell migration in the ascending aorta compared with Apoe(-/-) mice. local delivery of the SmgGDS gene construct reversed the dilation of the ascending aorta in Apoe(-/-) SmgGDS(+/-) mice.
Title: Small GTP-Binding Protein GDP Dissociation Stimulator Prevents Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic Preservation of Aortic Smooth Muscle Cells.
Simulated microgravity activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis.
Title: Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis.
results indicate that statins selectively up-regulate SmgGDS in endothelial cells, for which the beta1-integrin/Akt1 pathway may be involved, demonstrating the novel aspects of the pleiotropic effects of statins
Title: Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells.
These results indicate that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.
Title: Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE692247 (e-PCR)
- UniSTS:208489

PMC14890P1 (e-PCR)
- UniSTS:271026

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in CAAX-box protein maturation	IEA Inferred from Electronic Annotation more info
involved_in CAAX-box protein maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiotensin-activated signaling pathway involved in heart process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myosin filament assembly	IEA Inferred from Electronic Annotation more info
involved_in myosin filament assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endoplasmic reticulum calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endoplasmic reticulum calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of ERK5 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of matrix metallopeptidase secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to statin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular associated smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in vascular associated smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rap1 GTPase-GDP dissociation stimulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040690.3 → NP_001035780.1 rap1 GTPase-GDP dissociation stimulator 1 isoform a

Status: VALIDATED

Source sequence(s)

AC110574, AC113307, AC119881

Consensus CDS

CCDS51083.1

UniProtKB/Swiss-Prot

E9Q6Q4, E9Q912, I6L967, Q3TA69, Q3TLU4, Q3TPS9, Q3TU36

UniProtKB/TrEMBL

A0A0G2JGC8

Related

ENSMUSP00000096173.3, ENSMUST00000098574.9

Conserved Domains (4) summary

smart00185
Location:346 → 389

ARM; Armadillo/beta-catenin-like repeats

PLN03200
Location:42 → 264

PLN03200; cellulose synthase-interactive protein; Provisional

sd00043
Location:91 → 116

ARM; armadillo repeat [structural motif]

pfam00514
Location:86 → 117

Arm; Armadillo/beta-catenin-like repeat
NM_001286759.2 → NP_001273688.1 rap1 GTPase-GDP dissociation stimulator 1 isoform c

See identical proteins and their annotated locations for NP_001273688.1

Status: VALIDATED

Source sequence(s)

AC110574, AC113307, AC119881

Consensus CDS

CCDS80033.1

UniProtKB/TrEMBL

A0A0G2JGC8

Related

ENSMUSP00000143181.2, ENSMUST00000196280.5

Conserved Domains (2) summary

cd00020
Location:317 → 430

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:91 → 116

ARM; armadillo repeat [structural motif]
NM_001356388.2 → NP_001343317.1 rap1 GTPase-GDP dissociation stimulator 1 isoform d

Status: VALIDATED

Source sequence(s)

AC110574, AC113307, AC119881

UniProtKB/TrEMBL

A0A0G2JGC8

Conserved Domains (3) summary

pfam00514
Location:86 → 117

Arm; Armadillo/beta-catenin-like repeat

sd00043
Location:44 → 71

ARM; armadillo repeat [structural motif]

cl26969
Location:177 → 342

Vitellogenin_N; Lipoprotein amino terminal region
NM_001411343.1 → NP_001398272.1 rap1 GTPase-GDP dissociation stimulator 1 isoform e

Status: VALIDATED

Source sequence(s)

AC110574, AC113307, AC119881
NM_001411344.1 → NP_001398273.1 rap1 GTPase-GDP dissociation stimulator 1 isoform f

Status: VALIDATED

Source sequence(s)

AC110574, AC113307, AC119881
NM_001411345.1 → NP_001398274.1 rap1 GTPase-GDP dissociation stimulator 1 isoform g

Status: VALIDATED

Source sequence(s)

AC110574, AC113307, AC119881
NM_001411346.1 → NP_001398275.1 rap1 GTPase-GDP dissociation stimulator 1 isoform h

Status: VALIDATED

Source sequence(s)

AC110574, AC113307, AC119881
NM_001411347.1 → NP_001398276.1 rap1 GTPase-GDP dissociation stimulator 1 isoform i

Status: VALIDATED

Source sequence(s)

AC110574, AC113307, AC119881
NM_001411348.1 → NP_001398277.1 rap1 GTPase-GDP dissociation stimulator 1 isoform j

Status: VALIDATED

Source sequence(s)

AC110574, AC113307, AC119881
NM_001411349.1 → NP_001398278.1 rap1 GTPase-GDP dissociation stimulator 1 isoform k

Status: VALIDATED

Source sequence(s)

AC110574, AC113307, AC119881
NM_001411350.1 → NP_001398279.1 rap1 GTPase-GDP dissociation stimulator 1 isoform l

Status: VALIDATED

Source sequence(s)

AC110574, AC113307, AC119881
NM_145544.4 → NP_663519.2 rap1 GTPase-GDP dissociation stimulator 1 isoform b

Status: VALIDATED

Source sequence(s)

AC110574, AC113307, AC119881

Consensus CDS

CCDS51082.1

UniProtKB/TrEMBL

A0A0G2JGC8

Related

ENSMUSP00000029796.7, ENSMUST00000029796.11

Conserved Domains (2) summary

cd00020
Location:268 → 381

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:44 → 71

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

138631662..138781163 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252602.2 → XP_030108462.1 rap1 GTPase-GDP dissociation stimulator 1 isoform X1

Conserved Domains (3) summary

smart00185
Location:168 → 211

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:173 → 212

ARM; armadillo repeat [structural motif]

cl26969
Location:48 → 213

Vitellogenin_N; Lipoprotein amino terminal region
XM_036163086.1 → XP_036018979.1 rap1 GTPase-GDP dissociation stimulator 1 isoform X2

Conserved Domains (3) summary

smart00185
Location:168 → 211

ARM; Armadillo/beta-catenin-like repeats

PLN03200
Location:179 → 330

PLN03200; cellulose synthase-interactive protein; Provisional

sd00043
Location:173 → 212

ARM; armadillo repeat [structural motif]
XM_006501428.5 → XP_006501491.1 rap1 GTPase-GDP dissociation stimulator 1 isoform X1

See identical proteins and their annotated locations for XP_006501491.1

Conserved Domains (3) summary

smart00185
Location:168 → 211

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:173 → 212

ARM; armadillo repeat [structural motif]

cl26969
Location:48 → 213

Vitellogenin_N; Lipoprotein amino terminal region
XM_006501429.5 → XP_006501492.1 rap1 GTPase-GDP dissociation stimulator 1 isoform X1

See identical proteins and their annotated locations for XP_006501492.1

Conserved Domains (3) summary

smart00185
Location:168 → 211

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:173 → 212

ARM; armadillo repeat [structural motif]

cl26969
Location:48 → 213

Vitellogenin_N; Lipoprotein amino terminal region
XM_036163087.1 → XP_036018980.1 rap1 GTPase-GDP dissociation stimulator 1 isoform X3

Conserved Domains (4) summary

PLN03200
Location:42 → 264

PLN03200; cellulose synthase-interactive protein; Provisional

sd00043
Location:91 → 116

ARM; armadillo repeat [structural motif]

pfam00514
Location:86 → 117

Arm; Armadillo/beta-catenin-like repeat

cl26969
Location:226 → 393

Vitellogenin_N; Lipoprotein amino terminal region
XM_036163088.1 → XP_036018981.1 rap1 GTPase-GDP dissociation stimulator 1 isoform X4

Conserved Domains (3) summary

sd00043
Location:44 → 71

ARM; armadillo repeat [structural motif]

pfam00514
Location:86 → 117

Arm; Armadillo/beta-catenin-like repeat

cl26969
Location:177 → 344

Vitellogenin_N; Lipoprotein amino terminal region