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    Tcta T cell leukemia translocation altered gene [ Mus musculus (house mouse) ]

    Gene ID: 102791, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tctaprovided by MGI
    Official Full Name
    T cell leukemia translocation altered geneprovided by MGI
    Primary source
    MGI:MGI:1918829
    See related
    Ensembl:ENSMUSG00000039461 AllianceGenome:MGI:1918829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tctal; 9130410M22Rik
    Summary
    Predicted to be involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to be located in membrane. Is expressed in cranial ganglion; dorsal root ganglion; sensory organ; and trigeminal nerve. Orthologous to human TCTA (T cell leukemia translocation altered). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 28.4), genital fat pad adult (RPKM 27.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tcta in Genome Data Viewer
    Location:
    9 F2; 9 59.2 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108180157..108183174, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108302955..108306159, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2915 Neighboring gene nicolin 1 Neighboring gene aminomethyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E6805 Neighboring gene ras homolog family member A Neighboring gene STARR-seq mESC enhancer starr_25204 Neighboring gene STARR-seq mESC enhancer starr_25205 Neighboring gene glutathione peroxidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. Aplan PD, et al. Cancer Res, 1995 May 1. PMID 7728759
    2. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Persons DA, et al. Nat Genet, 1999 Oct. PMID 10508511
    3. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoclast fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in osteoclast fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-cell leukemia translocation-altered gene protein homolog
    Names
    T-cell leukemia translocation altered

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311156.2 → NP_001298085.1  T-cell leukemia translocation-altered gene protein homolog isoform 2

      See identical proteins and their annotated locations for NP_001298085.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC161260
      Consensus CDS
      CCDS81073.1
      UniProtKB/TrEMBL
      A0A0A6YXI4
      Related
      ENSMUSP00000142002.2, ENSMUST00000192886.6
      Conserved Domains (1) summary
      pfam15128
      Location:15 → 106
      T_cell_tran_alt; T-cell leukemia translocation-altered

    2. NM_133986.3 → NP_598747.1  T-cell leukemia translocation-altered gene protein homolog isoform 1

      See identical proteins and their annotated locations for NP_598747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC161260
      Consensus CDS
      CCDS23520.1
      UniProtKB/Swiss-Prot
      Q8VEA7
      Related
      ENSMUSP00000045063.8, ENSMUST00000044725.9
      Conserved Domains (1) summary
      pfam15128
      Location:15 → 122
      T_cell_tran_alt; T-cell leukemia translocation-altered

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108180157..108183174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEA7.1 GenPept UniProtKB/Swiss-Prot:Q8VEA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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