Or51e2 olfactory receptor family 51 subfamily E member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Or51e2provided by MGI
Official Full Name: olfactory receptor family 51 subfamily E member 2provided by MGI
Primary source: MGI:MGI:2157548
See related: Ensembl:ENSMUSG00000043366 AllianceGenome:MGI:2157548
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PSGR; RA1c; MOL2.3; Olfr78; MOR18-2; 4633402A21Rik
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 3.2), colon adult (RPKM 2.5) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 54.83 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (102389928..102408678, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (102740721..102759471, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The olfactory receptor Olfr78 promotes differentiation of enterochromaffin cells in the mouse colon.
Title: The olfactory receptor Olfr78 promotes differentiation of enterochromaffin cells in the mouse colon.
Olfactory receptor 78 is expressed in hypothalamic vasopressin/oxytocin neurons, parenchymal microglia and choroidal macrophages in mice.
Title: Olfactory receptor 78 is expressed in hypothalamic vasopressin/oxytocin neurons, parenchymal microglia and choroidal macrophages in mice.
Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.
Title: Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.
Olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) expression in arterioles supplying skeletal and cardiac muscles and in arterioles feeding some murine organs.
Title: Olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) expression in arterioles supplying skeletal and cardiac muscles and in arterioles feeding some murine organs.
Olfactory receptor 78 modulates renin but not baseline blood pressure.
Title: Olfactory receptor 78 modulates renin but not baseline blood pressure.
The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages.
Title: The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages.
Gut microbial short-chain fatty acids-mediated olfactory receptor 78 stimulation promotes anorexigenic gut hormone peptide YY secretion in mice.
Title: Gut microbial short-chain fatty acids-mediated olfactory receptor 78 stimulation promotes anorexigenic gut hormone peptide YY secretion in mice.
Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia.
Title: Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia.
Olfr-78 is highly expressed in colon and down-regulated in colitis.
Title: The olfactory G protein-coupled receptor (Olfr-78/OR51E2) modulates the intestinal response to colitis.
Transgenic mice overexpressing PSGR in the prostate were reported to develop an acute inflammatory response followed by emergence of low grade prostatic intraepithelial neoplasia, whereas mice with compound PSGR overexpression and loss of PTEN exhibited accelerated formation of invasive prostate adenocarcinoma. (Review)
Title: Prostate-Specific G-Protein Coupled Receptor, an Emerging Biomarker Regulating Inflammation and Prostate Cancer Invasion.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (6) 1 citation

General gene information

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Markers

BB462873 (e-PCR)
- UniSTS:208167

NoName (e-PCR)
- UniSTS:489519

12.MMHAP12FRD9.seq (e-PCR)
- UniSTS:123100

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear steroid receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear steroid receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	ISA Inferred from Sequence Alignment more info	PubMed
enables olfactory receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables olfactory receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IEA Inferred from Electronic Annotation more info
involved_in melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in melanocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in melanocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in melanocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of renin secretion into blood stream	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of smell	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within sensory perception of smell	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in steroid hormone receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: olfactory receptor 51E2

Names: GA_x6K02T2PBJ9-5459657-5458695; olfactory receptor 78; olfactory receptor MOR18-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168503.1 → NP_001161975.1 olfactory receptor 51E2

See identical proteins and their annotated locations for NP_001161975.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC162175, AK036356

Consensus CDS

CCDS21546.1

UniProtKB/Swiss-Prot

Q8VBV9

Related

ENSMUSP00000133255.2, ENSMUST00000168007.3

Conserved Domains (1) summary

cd15222
Location:24 → 298

7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_130866.4 → NP_570936.1 olfactory receptor 51E2

See identical proteins and their annotated locations for NP_570936.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC162175, AK028467, AK036356

Consensus CDS

CCDS21546.1

UniProtKB/Swiss-Prot

Q8VBV9

Related

ENSMUSP00000058085.8, ENSMUST00000060187.15

Conserved Domains (1) summary

cd15222
Location:24 → 298

7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors