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    Msi2 musashi RNA-binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 76626, updated on 9-Dec-2024

    Summary

    Official Symbol
    Msi2provided by MGI
    Official Full Name
    musashi RNA-binding protein 2provided by MGI
    Primary source
    MGI:MGI:1923876
    See related
    Ensembl:ENSMUSG00000069769 AllianceGenome:MGI:1923876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Msi2h; 1700105C15Rik
    Summary
    Enables poly(U) RNA binding activity. Involved in stem cell development. Located in cytoplasm. Is expressed in several structures, including central nervous system; gonad; hair follicle; limb bud; and sensory organ. Orthologous to human MSI2 (musashi RNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.7), whole brain E14.5 (RPKM 15.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Msi2 in Genome Data Viewer
    Location:
    11 C; 11 52.4 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (88230208..88609197, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88339382..88718306, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm439 Neighboring gene predicted gene, 34366 Neighboring gene coiled-coil domain containing 182 Neighboring gene microRNA 378b Neighboring gene STARR-seq mESC enhancer starr_30328 Neighboring gene predicted gene 11510 Neighboring gene STARR-seq mESC enhancer starr_30343 Neighboring gene STARR-positive B cell enhancer ABC_E10704 Neighboring gene RIKEN cDNA 0610039H22 gene Neighboring gene STARR-positive B cell enhancer mm9_chr11:88476068-88476369 Neighboring gene STARR-positive B cell enhancer ABC_E735 Neighboring gene STARR-seq mESC enhancer starr_30351 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:88488860-88488969 Neighboring gene STARR-seq mESC enhancer starr_30353 Neighboring gene STARR-seq mESC enhancer starr_30356 Neighboring gene STARR-seq mESC enhancer starr_30358 Neighboring gene RIKEN cDNA C030037D09 gene Neighboring gene STARR-seq mESC enhancer starr_30361 Neighboring gene STARR-positive B cell enhancer ABC_E5262 Neighboring gene STARR-seq mESC enhancer starr_30363 Neighboring gene RIKEN cDNA 4930556N13 gene Neighboring gene STARR-positive B cell enhancer ABC_E7042 Neighboring gene A kinase anchor protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC118040, MGC130496

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in stem cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RNA-binding protein Musashi homolog 2
    Names
    Musashi2
    musashi-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201341.1NP_001188270.1  RNA-binding protein Musashi homolog 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents an alternate splice pattern in the 3' coding region and UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL645601
      Consensus CDS
      CCDS48882.1
      UniProtKB/TrEMBL
      B1AT13
      Related
      ENSMUSP00000103541.2, ENSMUST00000107908.2
      Conserved Domains (1) summary
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    2. NM_001363194.1NP_001350123.1  RNA-binding protein Musashi homolog 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645601, AL732539, CR405681
      Conserved Domains (3) summary
      TIGR01628
      Location:35333
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:111184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
    3. NM_001363195.1NP_001350124.1  RNA-binding protein Musashi homolog 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK049637, AL645601, AL732539
      Consensus CDS
      CCDS88217.1
      UniProtKB/TrEMBL
      Q2M2Q8
      Related
      ENSMUSP00000103542.2, ENSMUST00000107909.8
      Conserved Domains (2) summary
      cd12323
      Location:111184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
    4. NM_001373923.1NP_001360852.1  RNA-binding protein Musashi homolog 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL645601, AL732539, CR405681
      Conserved Domains (2) summary
      cd12323
      Location:111184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
    5. NM_054043.3NP_473384.1  RNA-binding protein Musashi homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_473384.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BK001483, BQ174763
      Consensus CDS
      CCDS56796.1
      UniProtKB/Swiss-Prot
      Q8BQ90, Q920Q6, Q920Q7
      UniProtKB/TrEMBL
      Q3TE41
      Related
      ENSMUSP00000090470.6, ENSMUST00000092794.12
      Conserved Domains (3) summary
      TIGR01628
      Location:35343
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:111184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      88230208..88609197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249302.3XP_011247604.1  RNA-binding protein Musashi homolog 2 isoform X7

      See identical proteins and their annotated locations for XP_011247604.1

      Conserved Domains (3) summary
      TIGR01628
      Location:35351
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:111184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
    2. XM_036157065.1XP_036012958.1  RNA-binding protein Musashi homolog 2 isoform X13

      Conserved Domains (2) summary
      cd12323
      Location:135208
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17104
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
    3. XM_006534440.4XP_006534503.1  RNA-binding protein Musashi homolog 2 isoform X8

      Conserved Domains (3) summary
      TIGR01628
      Location:35349
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:135208
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    4. XM_006534435.4XP_006534498.1  RNA-binding protein Musashi homolog 2 isoform X3

      Conserved Domains (3) summary
      TIGR01628
      Location:35367
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:135208
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    5. XM_036157064.1XP_036012957.1  RNA-binding protein Musashi homolog 2 isoform X12

      Conserved Domains (2) summary
      cd12323
      Location:135208
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17104
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
    6. XM_006534438.4XP_006534501.1  RNA-binding protein Musashi homolog 2 isoform X6

      Conserved Domains (3) summary
      TIGR01628
      Location:35345
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:135208
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    7. XM_006534439.4XP_006534502.1  RNA-binding protein Musashi homolog 2 isoform X5

      Conserved Domains (3) summary
      TIGR01628
      Location:35357
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:135208
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    8. XM_006534431.4XP_006534494.1  RNA-binding protein Musashi homolog 2 isoform X2

      Conserved Domains (3) summary
      TIGR01628
      Location:35363
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:135208
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    9. XM_006534432.4XP_006534495.1  RNA-binding protein Musashi homolog 2 isoform X1

      Conserved Domains (3) summary
      TIGR01628
      Location:35375
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:135208
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    10. XM_006534441.5XP_006534504.1  RNA-binding protein Musashi homolog 2 isoform X10

      Conserved Domains (3) summary
      TIGR01628
      Location:35342
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:135208
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    11. XM_011249305.4XP_011247607.1  RNA-binding protein Musashi homolog 2 isoform X18

      See identical proteins and their annotated locations for XP_011247607.1

      Conserved Domains (2) summary
      TIGR01628
      Location:39266
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:2699
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    12. XM_030246417.1XP_030102277.1  RNA-binding protein Musashi homolog 2 isoform X19

      Conserved Domains (2) summary
      TIGR01628
      Location:39258
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:2699
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    13. XM_036157066.1XP_036012959.1  RNA-binding protein Musashi homolog 2 isoform X14

      Conserved Domains (2) summary
      TIGR01628
      Location:71298
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:58131
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    14. XM_036157067.1XP_036012960.1  RNA-binding protein Musashi homolog 2 isoform X15

      Conserved Domains (2) summary
      TIGR01628
      Location:71290
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:58131
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    15. XM_036157068.1XP_036012961.1  RNA-binding protein Musashi homolog 2 isoform X17

      Conserved Domains (2) summary
      cd12323
      Location:111184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
    16. XM_036157063.1XP_036012956.1  RNA-binding protein Musashi homolog 2 isoform X11

      Conserved Domains (2) summary
      cd12323
      Location:111184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
    17. XM_036157062.1XP_036012955.1  RNA-binding protein Musashi homolog 2 isoform X9

      Conserved Domains (3) summary
      TIGR01628
      Location:35337
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:135208
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cl17169
      Location:17104
      RRM_SF; RNA recognition motif (RRM) superfamily
    18. XM_006534434.4XP_006534497.1  RNA-binding protein Musashi homolog 2 isoform X4

      Conserved Domains (3) summary
      TIGR01628
      Location:35355
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:135208
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    19. XM_011249304.4XP_011247606.1  RNA-binding protein Musashi homolog 2 isoform X16

      Conserved Domains (2) summary
      cd12323
      Location:135208
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
    20. XM_030246418.2XP_030102278.1  RNA-binding protein Musashi homolog 2 isoform X20

      UniProtKB/TrEMBL
      B1AT13
      Conserved Domains (1) summary
      cd12576
      Location:2397
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    RNA

    1. XR_003949528.2 RNA Sequence

    2. XR_004937056.1 RNA Sequence

    3. XR_879764.3 RNA Sequence

    4. XR_388550.4 RNA Sequence

    5. XR_001780073.3 RNA Sequence