Tbx15 T-box 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tbx15provided by MGI
Official Full Name: T-box 15provided by MGI
Primary source: MGI:MGI:1277234
See related: Ensembl:ENSMUSG00000027868 AllianceGenome:MGI:1277234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: de; Tbx8; Tbx14; mmTBx8
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic cranial skeleton morphogenesis. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including branchial arch; facial prominence; genitourinary system; limb; and limb bud. Orthologous to human TBX15 (T-box transcription factor 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in limb E14.5 (RPKM 21.8), mammary gland adult (RPKM 8.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 43.03 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (99147671..99261576)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (99240348..99354260)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Tbx15 regulates adipocyte browning and might be a potential target for the treatment of obesity.
Title: Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway.
These studies showed that Tbx15 differentially regulates oxidative and glycolytic metabolism within subpopulations of white adipocytes and preadipocytes.
Title: Tbx15 Defines a Glycolytic Subpopulation and White Adipocyte Heterogeneity.
Tbx15 is one of a limited number of transcription factors to be identified with a critical role in regulating glycolytic fibre identity and muscle metabolism.
Title: Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism.
Tbx15 may be essential for the development of the adipogenic and thermogenic programs in adipocytes/adipomyocytes capable of developing brown adipocyte features
Title: An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes.
Study establish that expression of Tbx15, Prrx1, and Pax1, among other genes involved in the specification and development of select pelvic structures, is altered in our compound mutants.
Title: Control of pelvic girdle development by genes of the Pbx family and Emx2.
Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration.
Title: Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration.
phenotypes result from competition between the ectopically expressed Tbx6 and the endogenously expressed Tbx18 and Tbx15 at the binding sites of target genes
Title: Tbx18 and Tbx15 null-like phenotypes in mouse embryos expressing Tbx6 in somitic and lateral plate mesoderm.
Tbx15 has a role in mouse coat dorsoventral patterning
Title: Dorsoventral patterning of the mouse coat by Tbx15.
Tbx15 plays an important role in the development of the skeleton of the limb, vertebral column and head by controlling the number of mesenchymal precursor cells and chondrocytes
Title: The T-box transcription factor Tbx15 is required for skeletal development.
Tbx15 and Gli3 appear to have synergistic functions in formation of the scapular blade
Title: Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Spontaneous (2) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC314463P4 (e-PCR)
- UniSTS:272953

MARC_16759-16760:1020873220:1 (e-PCR)
- UniSTS:268103

RH126459 (e-PCR)
- UniSTS:163167

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: T-box transcription factor TBX15

Names: T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; droopy ear

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410561.1 → NP_001397490.1 T-box transcription factor TBX15 isoform 2

Status: VALIDATED

Source sequence(s)

AC080018, AL606745, AL606747
NM_001410562.1 → NP_001397491.1 T-box transcription factor TBX15 isoform 2

Status: VALIDATED

Source sequence(s)

AL606745, AL606747
NM_009323.3 → NP_033349.2 T-box transcription factor TBX15 isoform 1

See identical proteins and their annotated locations for NP_033349.2

Status: VALIDATED

Source sequence(s)

AC080018, AL606745, AL606747

Consensus CDS

CCDS17673.1

UniProtKB/Swiss-Prot

O54840, O70306, Q5GBG1

Related

ENSMUSP00000029462.6, ENSMUST00000029462.10

Conserved Domains (1) summary

cd00182
Location:113 → 308

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

99147671..99261576

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501279.5 → XP_006501342.1 T-box transcription factor TBX15 isoform X1

See identical proteins and their annotated locations for XP_006501342.1

Conserved Domains (1) summary

cd20198
Location:1 → 198

T-box_TBX15-like; DNA-binding domain of T-box transcription factor 15 and related T-box proteins