Slco3a1 solute carrier organic anion transporter family, member 3a1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slco3a1provided by MGI
Official Full Name: solute carrier organic anion transporter family, member 3a1provided by MGI
Primary source: MGI:MGI:1351867
See related: Ensembl:ENSMUSG00000025790 AllianceGenome:MGI:1351867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Anr1; MJAM; OATP-D; Slc21a11; 5830414C08Rik
Summary: Predicted to enable prostaglandin transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; prostaglandin transport; and sodium-independent organic anion transport. Predicted to be located in basal plasma membrane. Predicted to be active in basolateral plasma membrane. Is expressed in nervous system and thyroid gland. Orthologous to human SLCO3A1 (solute carrier organic anion transporter family member 3A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 34.1), ovary adult (RPKM 22.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 42.95 cM; 7 D1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (73925166..74204528, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (74275418..74554780, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals.
Title: Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals.
Expression of St8sia2 and Slco3a1 was significantly altered in metabolically active tissues in Roux-en-Y gastric bypass-treated compared to weight-matched, sham-operated mice.
Title: Weight loss after gastric bypass is associated with a variant at 15q26.1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Mit201 (e-PCR), detects polymorphism
- UniSTS:131094

Slco3a1 (e-PCR), detects polymorphism
- UniSTS:547142

31.MMHAP61FRC10.seq (e-PCR)
- UniSTS:159652

NoName (e-PCR)
- UniSTS:235691

SLC21A11_1798 (e-PCR)
- UniSTS:281007

RH125163 (e-PCR)
- UniSTS:161985

D7Mit147 (e-PCR), detects polymorphism
- UniSTS:131044

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in oligopeptide transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin transport	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 3A1

Names: androgen regulated protein 1; organic anion-transporting polypeptide D; sodium-independent organic anion transporter D; solute carrier family 21 (organic anion transporter), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038643.1 → NP_001033732.1 solute carrier organic anion transporter family member 3A1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site used in variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC114591, AK031280, AK037938

Consensus CDS

CCDS21366.1

UniProtKB/TrEMBL

D3YXA8

Related

ENSMUSP00000095973.3, ENSMUST00000098371.9

Conserved Domains (1) summary

cd17402
Location:39 → 563

MFS_SLCO3_OATP3; Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters
NM_023908.2 → NP_076397.2 solute carrier organic anion transporter family member 3A1 isoform 1

See identical proteins and their annotated locations for NP_076397.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AK031280, AK046945, AK152488

Consensus CDS

CCDS21367.1

UniProtKB/Swiss-Prot

Q3TLX2, Q3U7W0, Q505P2, Q544H3, Q8R3L5, Q9CTV3, Q9JKV0

UniProtKB/TrEMBL

D3YXA8

Related

ENSMUSP00000026897.8, ENSMUST00000026897.14

Conserved Domains (1) summary

cd17402
Location:39 → 563

MFS_SLCO3_OATP3; Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters