Cxcl11 chemokine (C-X-C motif) ligand 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cxcl11provided by MGI
Official Full Name: chemokine (C-X-C motif) ligand 11provided by MGI
Primary source: MGI:MGI:1860203
See related: AllianceGenome:MGI:1860203
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ip9; H174; Itac; b-R1; Cxc11; I-tac; Scyb11; Scyb9b; betaR1
Summary: Predicted to enable CXCR3 chemokine receptor binding activity; chemokine activity; and heparin binding activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; leukocyte chemotaxis; and positive regulation of release of sequestered calcium ion into cytosol. Predicted to be active in extracellular space. Is expressed in head; nasal cavity epithelium; palatal shelf epithelium; palatal shelf mesenchyme; and testis. Orthologous to human CXCL11 (C-X-C motif chemokine ligand 11). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 5 E2; 5 46.61 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (92507403..92511155, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (92359544..92363296, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain.
Title: Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain.
Chemokine redundancy versus specificity in the context of CXCR3 and its ligands.
Title: Chemokine redundancy versus specificity in the context of CXCR3 and its ligands.
CXCL11 expressing C57BL/6 mice have intact adaptive immune responses to viral infection.
Title: CXCL11 expressing C57BL/6 mice have intact adaptive immune responses to viral infection.
Obesity is common in alcoholic hepatitis (AH) and associated with a greater than two-fold increase in short-term mortality. Obese AH is associated with a different inflammatory phenotype, with the greatest elevation in CXCL11
Title: Obesity in acute alcoholic hepatitis increases morbidity and mortality.
although the expression of CXCL9 and CXCL11 are increased after spinal nerve ligation, they may not contribute to the maintenance of neuropathic pain.
Title: Spinal CXCL9 and CXCL11 are not involved in neuropathic pain despite an upregulation in the spinal cord following spinal nerve injury.
These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis
Title: Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes.
very low doses of CXCL11 rapidly suppress signs of EAE in C57BL/6 mice lacking functional CXCL11.
Title: CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.
Data indicate that epidermis-derived I-TAC (Cxcl11) triggers a sustained Th2-response that determines the outcome of a complex immunological process.
Title: Epidermal expression of I-TAC (Cxcl11) instructs adaptive Th2-type immunity.
Analysis of genes within the Listr1 locus identified a frameshift mutation in the Cxcl11 gene of the C57BL/6 strain that prevents production of the mature chemokine CXCL11.
Title: Listr1 locus regulates innate immunity against Listeria monocytogenes infection in the mouse liver possibly through Cxcl11 polymorphism.
Cxcl10 and cxcl11 are new hair-specific transcriptional targets of ectodysplasin, and they indicates involvement of chemokines in hair development.
Title: Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Spontaneous (1) 1 citation

General gene information

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Markers

Scyb11 (e-PCR), detects polymorphism
- UniSTS:166289

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CXCR3 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables CXCR3 chemokine receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables chemokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables chemokine activity	TAS Traceable Author Statement more info	PubMed
enables heparin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C motif chemokine 11

Names: interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small-inducible cytokine B11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019494.1 → NP_062367.1 C-X-C motif chemokine 11 precursor

See identical proteins and their annotated locations for NP_062367.1

Status: VALIDATED

Description

Transcript Variant: This variant (1, coding) represents the shorter transcript but encodes the functional protein. This variant, which is based on a transcript from the BALB/c mouse strain, includes a 1-nt insertion in the 5'-most exon compared to the reference genome sequence, which represents a null mutant allele (C57BL/6 strain).

Source sequence(s)

AF179872

UniProtKB/Swiss-Prot

Q9JHH5

UniProtKB/TrEMBL

Q8R392

Conserved Domains (1) summary

cd00273
Location:27 → 91

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RNA

NR_038116.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1, non-coding) includes a 1-nt deletion in the 5'-most exon, and it represents the non-functional reference genome allele (C57BL/6 strain), compared to variant 1. This variant is represented as non-coding because the use of the supported start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This gene is known to be non-functional in C57BL/6 mice, supported by data in PMID:17804806.

Source sequence(s)

AC122365, AK020750