Kpna4 karyopherin subunit alpha 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kpna4provided by MGI
Official Full Name: karyopherin subunit alpha 4provided by MGI
Primary source: MGI:MGI:1100848
See related: Ensembl:ENSMUSG00000027782 AllianceGenome:MGI:1100848
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: qip1; IPOA3; 1110058D08Rik
Summary: Enables nuclear import signal receptor activity. Acts upstream of or within protein import into nucleus and response to hydrogen peroxide. Located in male germ cell nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human KPNA4 (karyopherin subunit alpha 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 14.2), CNS E11.5 (RPKM 14.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E1; 3 32.18 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (68979554..69034425, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (69072221..69127092, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Importin- alpha -Mediated Nuclear Localization of Dendrin Attenuates Podocyte Loss and Glomerulosclerosis.
Title: Inhibition of Importin- α -Mediated Nuclear Localization of Dendrin Attenuates Podocyte Loss and Glomerulosclerosis.
Importin alpha3 regulates chronic pain pathways in peripheral sensory neurons.
Title: Importin α3 regulates chronic pain pathways in peripheral sensory neurons.
Our results showed that miR-181 family expression was closely correlated with TCGA subtypes and patients' overall survival, indicating that miR-181b.
Title: Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma.
Loss of importin alpha 4 is associated with oxidative stress.
Title: The nuclear import factor importin α4 can protect against oxidative stress.
IMPalpha4 overexpression induced a significant decrease in Oct3/4 protein levels compared to control transfections. IMPalpha4 protein showed a unique and striking shift in subcellular localization from the nucleus to the cytoplasm during differentiation.
Title: Distinct effects of importin α2 and α4 on Oct3/4 localization and expression in mouse embryonic stem cells.
Expression of importin alpha3, a protein involved in p50/p65 nuclear import, was decreased in colonic mucosa cells of transgenic mice overexpressing human prohibitin.
Title: Prohibitin inhibits tumor necrosis factor alpha-induced nuclear factor-kappa B nuclear translocation via the novel mechanism of decreasing importin alpha3 expression.
In postnatal testes, importin alpha3 and alpha4 in spermatocytes, spermatids, and Sertoli cells display cytoplasmic and nuclear localization, respectively.
Title: Subcellular distribution of importins correlates with germ cell maturation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WIAF-1631 (e-PCR)
- UniSTS:19006

Kpna4 (e-PCR), detects polymorphism
- UniSTS:507011

AU021871 (e-PCR)
- UniSTS:207506

AA924555 (e-PCR)
- UniSTS:248215

HSC0TF112 (e-PCR)
- UniSTS:76455

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_positive_effect dopamine secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NLS-dependent protein nuclear import complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: importin subunit alpha-3

Names: importin alpha 3; importin alpha Q1; importin subunit alpha-4; karyopherin (importin) alpha 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008467.4 → NP_032493.1 importin subunit alpha-3

See identical proteins and their annotated locations for NP_032493.1

Status: PROVISIONAL

Source sequence(s)

AC119847

Consensus CDS

CCDS17403.1

UniProtKB/Swiss-Prot

O35343

UniProtKB/TrEMBL

Q3UGH8, Q4FJX1

Related

ENSMUSP00000141227.2, ENSMUST00000194558.6

Conserved Domains (2) summary

COG5064
Location:11 → 513

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:279 → 311

ARM; armadillo repeat [structural motif]