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    Tob2 transducer of ERBB2, 2 [ Mus musculus (house mouse) ]

    Gene ID: 57259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tob2provided by MGI
    Official Full Name
    transducer of ERBB2, 2provided by MGI
    Primary source
    MGI:MGI:1888525
    See related
    Ensembl:ENSMUSG00000048546 AllianceGenome:MGI:1888525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1663; 2900090N22Rik; 4930545K18Rik
    Summary
    Enables nuclear vitamin D receptor binding activity. Acts upstream of or within negative regulation of osteoclast differentiation; positive regulation of ossification; and regulation of gene expression. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Meckel's cartilage; cerebral cortex; genitourinary system; lens; and orbito-sphenoid. Orthologous to human TOB2 (transducer of ERBB2, 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 33.9), thymus adult (RPKM 22.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tob2 in Genome Data Viewer
    Location:
    15 E1; 15 38.26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81732471..81744742, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81848270..81858326, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E944 Neighboring gene thyrotroph embryonic factor Neighboring gene STARR-positive B cell enhancer ABC_E8940 Neighboring gene STARR-positive B cell enhancer ABC_E8599 Neighboring gene predicted gene 8444 Neighboring gene STARR-positive B cell enhancer ABC_E7399 Neighboring gene STARR-positive B cell enhancer ABC_E481 Neighboring gene PHD finger protein 5A Neighboring gene aconitase 2, mitochondrial Neighboring gene STARR-seq mESC enhancer starr_39272 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the mouse tob2 gene. Ajima R, et al. Gene, 2000 Aug 8. PMID 10940559
    2. MiR-5100 promotes osteogenic differentiation by targeting Tob2. Wang H, et al. J Bone Miner Metab, 2017 Nov. PMID 27873073
    3. Tob2 Inhibits TLR-Induced Inflammatory Responses by Association with TRAF6 and MyD88. Jiang G, et al. J Immunol, 2020 Aug 15. PMID 32611726
    4. BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation. Chen Y, et al. Biochem Biophys Res Commun, 2015 Jul 3. PMID 25951976
    5. MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability. Gámez B, et al. J Biol Chem, 2013 May 17. PMID 23564456, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells.
      Title: TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells.
    2. Tob2 Inhibits TLR-Induced Inflammatory Responses by Association with TRAF6 and MyD88.
      Title: Tob2 Inhibits TLR-Induced Inflammatory Responses by Association with TRAF6 and MyD88.
    3. These results revealed a new molecular mechanism that fine-tunes osteoblast differentiation through miR-5100/Tob2/osterix networks.
      Title: MiR-5100 promotes osteogenic differentiation by targeting Tob2.
    4. Tob1(-/-), Tob2(-/-), and Tob1/2 double knockout (DKO, Tob1(-/-) & Tob2(-/-)) embryonic stem cells (ESCs) grew faster than wild type (WT) ESCs without losing pluripotency.
      Title: BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation.
    5. miR-322 and its target protein Tob2 modulate Osx mRNA stability
      Title: MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability.
    6. Tob2 protein suppresses PPARgamma2 transcription by inhibiting BMP2-induced Smad1/5 phosphorylation through its interaction with Smad6 and by sequestering C/EBPalpha from the PPARgamma2 promoter.
      Title: Tob2 inhibits peroxisome proliferator-activated receptor γ2 expression by sequestering Smads and C/EBPα during adipocyte differentiation.
    7. Tob2 negatively regulates formation of osteoclasts by suppressing RANKL expression through its interaction with vitamin D receptor
      Title: Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear vitamin D receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein Tob2
    Names
    transducer of erbB-2 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020507.3 → NP_065253.1  protein Tob2

      See identical proteins and their annotated locations for NP_065253.1

      Status: VALIDATED

      Source sequence(s)
      AK049766, AK143542, AV220845, CK618657, DV644744
      Consensus CDS
      CCDS27673.1
      UniProtKB/Swiss-Prot
      Q9JM55
      UniProtKB/TrEMBL
      Q543X9, Q80TA8
      Related
      ENSMUSP00000061390.8, ENSMUST00000050467.9
      Conserved Domains (1) summary
      cl15439
      Location:1 → 106
      BTG; BTG family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81732471..81744742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159530.1 → XP_036015423.1  protein Tob2 isoform X1

      UniProtKB/Swiss-Prot
      Q9JM55
      UniProtKB/TrEMBL
      Q543X9, Q80TA8
      Conserved Domains (1) summary
      cl15439
      Location:1 → 106
      BTG; BTG family

    2. XM_036159531.1 → XP_036015424.1  protein Tob2 isoform X1

      UniProtKB/Swiss-Prot
      Q9JM55
      UniProtKB/TrEMBL
      Q543X9, Q80TA8
      Conserved Domains (1) summary
      cl15439
      Location:1 → 106
      BTG; BTG family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JM55.1 GenPept UniProtKB/Swiss-Prot:Q9JM55

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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