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    Dock4 dedicator of cytokinesis 4 [ Mus musculus (house mouse) ]

    Gene ID: 238130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dock4provided by MGI
    Official Full Name
    dedicator of cytokinesis 4provided by MGI
    Primary source
    MGI:MGI:1918006
    See related
    Ensembl:ENSMUSG00000035954 AllianceGenome:MGI:1918006
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0716; 5330406C03; C030023J22; 6330411N01Rik
    Summary
    Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in cell chemotaxis; negative regulation of vascular associated smooth muscle contraction; and positive regulation of vascular associated smooth muscle cell migration. Located in stereocilium. Is expressed in dorsal aorta; ovary; and testis. Orthologous to human DOCK4 (dedicator of cytokinesis 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 9.4), lung adult (RPKM 8.7) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dock4 in Genome Data Viewer
    Location:
    12 B1; 12 18.06 cM
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40495956..40896873)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40445957..40846874)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31954 Neighboring gene STARR-positive B cell enhancer mm9_chr12:40983751-40984051 Neighboring gene STARR-seq mESC enhancer starr_31955 Neighboring gene predicted gene, 40403 Neighboring gene STARR-seq mESC enhancer starr_31956 Neighboring gene zinc finger protein 277 Neighboring gene STARR-seq mESC enhancer starr_31957 Neighboring gene STARR-seq mESC enhancer starr_31958 Neighboring gene STARR-positive B cell enhancer mm9_chr12:41172293-41172594 Neighboring gene predicted gene, 40406 Neighboring gene STARR-seq mESC enhancer starr_31959 Neighboring gene STARR-seq mESC enhancer starr_31960 Neighboring gene STARR-seq mESC enhancer starr_31961 Neighboring gene STARR-seq mESC enhancer starr_31962 Neighboring gene STARR-seq mESC enhancer starr_31963 Neighboring gene STARR-seq mESC enhancer starr_31965 Neighboring gene STARR-seq mESC enhancer starr_31966 Neighboring gene predicted gene, 19441 Neighboring gene SET translocation pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age. Guo D, et al. Cell Mol Neurobiol, 2023 Apr. PMID 35635601
    2. DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function. Yazbeck P, et al. Arterioscler Thromb Vasc Biol, 2022 Jul. PMID 35477279, Free PMC Article
    3. Altered postnatal developmental patterns of ultrasonic vocalizations in Dock4 knockout mice. Yang X, et al. Behav Brain Res, 2021 May 21. PMID 33705839
    4. Two Autism/Dyslexia Linked Variations of DOCK4 Disrupt the Gene Function on Rac1/Rap1 Activation, Neurite Outgrowth, and Synapse Development. Huang M, et al. Front Cell Neurosci, 2019. PMID 32009906, Free PMC Article
    5. Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function. Guo D, et al. Mol Psychiatry, 2021 May. PMID 31388105, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age.
      Title: Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age.
    2. DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function.
      Title: DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function.
    3. DOCK4 regulates ghrelin production in gastric X/A-like cells.
      Title: DOCK4 regulates ghrelin production in gastric X/A-like cells.
    4. Altered postnatal developmental patterns of ultrasonic vocalizations in Dock4 knockout mice.
      Title: Altered postnatal developmental patterns of ultrasonic vocalizations in Dock4 knockout mice.
    5. DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation.
      Title: DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation.
    6. Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function.
      Title: Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function.
    7. SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
      Title: SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.
    8. Dock4 binds to SH3YL1 through the C-terminal proline-rich region.
      Title: Dock4 forms a complex with SH3YL1 and regulates cancer cell migration.
    9. The Atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.
      Title: The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.
    10. Rac-DOCK4-actin-binding protein harmonin-activated signaling pathway is possibly involved in regulating actin cytoskeleton organization in stereocilia of the inner ear.
      Title: An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of vascular associated smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of vascular associated smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular associated smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stereocilium bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172803.2 → NP_766391.2  dedicator of cytokinesis protein 4

      See identical proteins and their annotated locations for NP_766391.2

      Status: VALIDATED

      Source sequence(s)
      AK122353, BB641326, CAAA01013241
      Consensus CDS
      CCDS25895.1
      UniProtKB/Swiss-Prot
      B2RUG6, P59764
      Related
      ENSMUSP00000047387.7, ENSMUST00000037488.8
      Conserved Domains (4) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1206 → 1596
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      40495956..40896873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515085.3 → XP_006515148.1  dedicator of cytokinesis protein 4 isoform X1

      Conserved Domains (5) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1206 → 1596
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam03154
      Location:1731 → 1937
      Atrophin-1; Atrophin-1 family
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    2. XM_006515089.3 → XP_006515152.1  dedicator of cytokinesis protein 4 isoform X6

      Conserved Domains (4) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1206 → 1596
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    3. XM_006515090.3 → XP_006515153.1  dedicator of cytokinesis protein 4 isoform X7

      UniProtKB/TrEMBL
      A0A1Y7VLY2
      Related
      ENSMUSP00000152420.2, ENSMUST00000220912.2
      Conserved Domains (4) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1206 → 1596
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    4. XM_006515088.3 → XP_006515151.1  dedicator of cytokinesis protein 4 isoform X4

      Conserved Domains (4) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1206 → 1596
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    5. XM_030246698.1 → XP_030102558.1  dedicator of cytokinesis protein 4 isoform X5

      Conserved Domains (5) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1206 → 1596
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam06484
      Location:1701 → 1832
      Ten_N; Teneurin Intracellular Region
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    6. XM_017315054.2 → XP_017170543.1  dedicator of cytokinesis protein 4 isoform X9

      Conserved Domains (4) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1206 → 1596
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    7. XM_006515086.3 → XP_006515149.1  dedicator of cytokinesis protein 4 isoform X2

      Conserved Domains (5) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1197 → 1587
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam03154
      Location:1722 → 1928
      Atrophin-1; Atrophin-1 family
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    8. XM_006515087.3 → XP_006515150.1  dedicator of cytokinesis protein 4 isoform X3

      Conserved Domains (5) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1197 → 1587
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam06484
      Location:1710 → 1841
      Ten_N; Teneurin Intracellular Region
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    9. XM_036157392.1 → XP_036013285.1  dedicator of cytokinesis protein 4 isoform X8

      Conserved Domains (4) summary
      cd08695
      Location:400 → 584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:1197 → 1587
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:10 → 65
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69 → 392
      DOCK_N; DOCK N-terminus

    RNA

    1. XR_004937494.1 RNA Sequence

    2. XR_004937497.1 RNA Sequence

    3. XR_004937495.1 RNA Sequence

    4. XR_004937496.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59764.1 GenPept UniProtKB/Swiss-Prot:P59764

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