Trpc7 transient receptor potential cation channel, subfamily C, member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpc7provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily C, member 7provided by MGI
Primary source: MGI:MGI:1349470
See related: Ensembl:ENSMUSG00000021541 AllianceGenome:MGI:1349470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TRP7; Trrp8
Summary: The protein encoded by this gene is a member of the transient receptor potential channel family of proteins, which form six-transmembrane cation-permeable channels that are calcium permeant. Knock out mice are viable but display a reduction in the gamma wave activity that precedes seizure induction in response to a muscrarinic agonist, suggesting a functional role for this protein in initiation of seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression: Biased expression in CNS E18 (RPKM 2.1), frontal lobe adult (RPKM 1.3) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 30.27 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (56920911..57043778, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (56773098..56895968, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct Morphological and Behavioural Alterations in ENU-Induced Heterozygous Trpc7(K810Stop) Mutant Mice.
Title: Distinct Morphological and Behavioural Alterations in ENU-Induced Heterozygous Trpc7(K810Stop) Mutant Mice.
TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes.
Title: TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes.
The injury phase after myocardial infarcts occurs during reperfusion and is a consequence of calcium release from internal stores combined with calcium entry, leading to cell death. We identify canonical transient receptor potential channels (TRPC) 3/6/7 as the cation channels through which most of the damaging calcium enters cells to trigger their death, and we describe mechanisms activated during the injury phase.
Title: Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.
TRPC7 is intimately involved in the initiation of seizures both in vitro and in vivo.
Title: Critical role of canonical transient receptor potential channel 7 in initiation of seizures.
These results demonstrate that the melanopsin-evoked depolarization in retinal ganglion cells is not mediated by either TRPC3, TRPC6 or TRPC7 channel subunits alone.
Title: Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits.
TRPC channels are necessary mediators of pathologic cardiac hypertrophy, in part through a calcineurin-NFAT signaling pathway
Title: TRPC channels are necessary mediators of pathologic cardiac hypertrophy.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

Trpc7 (e-PCR), detects polymorphism
- UniSTS:546051

D13Mit185 (e-PCR), detects polymorphism
- UniSTS:127001

BB254000 (e-PCR)
- UniSTS:208939

Trpc7 (e-PCR), detects polymorphism
- UniSTS:531244

Trpc7 (e-PCR), detects polymorphism
- UniSTS:516718

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in single fertilization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: short transient receptor potential channel 7

Names: transient receptor potential protein homologue TRP7; transient receptor protein 7; transient receptor protein 8

NP_001289301.1

EC 3.6.1.13

NP_001289302.1

EC 3.6.1.13

NP_036165.1

EC 3.6.1.13

XP_006517325.1

EC 3.6.1.13

XP_006517326.1

EC 3.6.1.13

XP_006517327.1

EC 3.6.1.13

XP_036013952.1

EC 3.6.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302372.1 → NP_001289301.1 short transient receptor potential channel 7 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.

Source sequence(s)

AC132322, AC132886, AK135153, AK137418

Consensus CDS

CCDS79192.1

UniProtKB/TrEMBL

E9PVJ9, Q3UXW9

Related

ENSMUSP00000105497.2, ENSMUST00000109871.8

Conserved Domains (5) summary

cd00204
Location:51 → 184

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:27 → 821

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:198 → 256

TRP_2; Transient receptor ion channel II

sd00045
Location:77 → 108

ANK; ANK repeat [structural motif]

cl00511
Location:582 → 665

FTSW_RODA_SPOVE; Cell cycle protein
NM_001302373.1 → NP_001289302.1 short transient receptor potential channel 7 isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 3, which has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC132886, AK135153, AK137418

UniProtKB/TrEMBL

Q3UXW9

Conserved Domains (2) summary

pfam00520
Location:52 → 299

Ion_trans; Ion transport protein

cl00511
Location:197 → 280

FTSW_RODA_SPOVE; Cell cycle protein
NM_012035.3 → NP_036165.1 short transient receptor potential channel 7 isoform 1

See identical proteins and their annotated locations for NP_036165.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC132322, AC132886, AK135153, AK137418

Consensus CDS

CCDS26566.1

UniProtKB/Swiss-Prot

Q9WVC5

UniProtKB/TrEMBL

Q0VFY2, Q3UXW9

Related

ENSMUSP00000022023.7, ENSMUST00000022023.13

Conserved Domains (5) summary

cd00204
Location:51 → 184

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:27 → 822

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:198 → 256

TRP_2; Transient receptor ion channel II

sd00045
Location:77 → 108

ANK; ANK repeat [structural motif]

cl00511
Location:582 → 665

FTSW_RODA_SPOVE; Cell cycle protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

56920911..57043778 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517263.5 → XP_006517326.1 short transient receptor potential channel 7 isoform X3

UniProtKB/TrEMBL

G3UWT1

Related

ENSMUSP00000133411.2, ENSMUST00000173817.9

Conserved Domains (2) summary

TIGR00870
Location:126 → 860

trp; transient-receptor-potential calcium channel protein

sd00045
Location:176 → 207

ANK; ANK repeat [structural motif]
XM_036158059.1 → XP_036013952.1 short transient receptor potential channel 7 isoform X2

UniProtKB/TrEMBL

G3UWI6

Conserved Domains (2) summary

TIGR00870
Location:126 → 865

trp; transient-receptor-potential calcium channel protein

sd00045
Location:176 → 207

ANK; ANK repeat [structural motif]
XM_006517262.5 → XP_006517325.1 short transient receptor potential channel 7 isoform X1

UniProtKB/TrEMBL

G3UWI6

Related

ENSMUSP00000133305.2, ENSMUST00000174457.9

Conserved Domains (2) summary

TIGR00870
Location:126 → 866

trp; transient-receptor-potential calcium channel protein

sd00045
Location:176 → 207

ANK; ANK repeat [structural motif]
XM_006517264.5 → XP_006517327.1 short transient receptor potential channel 7 isoform X4

UniProtKB/TrEMBL

G3UZW6

Related

ENSMUSP00000134662.3, ENSMUST00000173513.9

Conserved Domains (2) summary

TIGR00870
Location:126 → 805

trp; transient-receptor-potential calcium channel protein

sd00045
Location:176 → 207

ANK; ANK repeat [structural motif]