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    Fgg fibrinogen gamma chain [ Mus musculus (house mouse) ]

    Gene ID: 99571, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fggprovided by MGI
    Official Full Name
    fibrinogen gamma chainprovided by MGI
    Primary source
    MGI:MGI:95526
    See related
    Ensembl:ENSMUSG00000033860 AllianceGenome:MGI:95526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3010002H13Rik
    Summary
    This gene encodes the gamma subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Mice lacking the encoded protein did not possess detectable amounts of plasma fibrinogen. Pregnant mice lacking the encoded protein die due to heavy bleeding during delivery. This gene is located adjacent to the genes encoding fibrinogen alpha and gamma subunits on chromosome 3. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in liver E18 (RPKM 2199.8), liver adult (RPKM 856.8) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Fgg in Genome Data Viewer
    Location:
    3 E3; 3 36.94 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (82915031..82922363)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (83007724..83015056)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 46 Neighboring gene RNA binding motif protein 46, opposite strand Neighboring gene lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) Neighboring gene predicted gene, 30097 Neighboring gene STARR-seq mESC enhancer starr_08043 Neighboring gene predicted gene, 40075 Neighboring gene fibrinogen alpha chain

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding  
    enables extracellular matrix structural constituent PubMed 
    enables identical protein binding  
    enables metal ion binding  
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables structural molecule activity  
    Process Evidence Code Pubs
    involved_in adaptive immune response  
    involved_in blood coagulation, fibrin clot formation  
    involved_in cell-matrix adhesion  
    involved_in cell-matrix adhesion  
    involved_in fibrinolysis  
    involved_in innate immune response  
    involved_in negative regulation of endothelial cell apoptotic process  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in plasminogen activation  
    involved_in platelet activation  
    involved_in platelet aggregation  
    involved_in platelet aggregation  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of exocytosis  
    involved_in positive regulation of heterotypic cell-cell adhesion  
    involved_in positive regulation of peptide hormone secretion  
    involved_in positive regulation of protein secretion  
    involved_in positive regulation of vasoconstriction  
    involved_in protein polymerization  
    involved_in protein polymerization  
    involved_in protein secretion  
    involved_in protein-containing complex assembly  
    involved_in response to calcium ion  
    Component Evidence Code Pubs
    located_in blood microparticle  
    located_in cell cortex PubMed 
    located_in cell surface  
    located_in collagen-containing extracellular matrix PubMed 
    is_active_in collagen-containing extracellular matrix  
    located_in external side of plasma membrane  
    is_active_in extracellular space  
    located_in extracellular space  
    part_of fibrinogen complex  
    part_of fibrinogen complex  
    located_in platelet alpha granule  
    is_active_in synapse PubMed 
    is_active_in synapse PubMed 

    General protein information

    Preferred Names
    fibrinogen gamma chain
    Names
    fibrinogen, gamma polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317105.1NP_001304034.1  fibrinogen gamma chain isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC138394, AK149375, AW113409, BY793963
      Consensus CDS
      CCDS84633.1
      UniProtKB/TrEMBL
      Q3UER8
      Related
      ENSMUSP00000141648.2, ENSMUST00000194175.2
      Conserved Domains (2) summary
      pfam08702
      Location:30171
      Fib_alpha; Fibrinogen alpha/beta chain family
      cl00085
      Location:174413
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    2. NM_133862.2NP_598623.1  fibrinogen gamma chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_598623.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC138394, AK149448, BP772517, BY793963
      Consensus CDS
      CCDS38462.1
      UniProtKB/Swiss-Prot
      Q8VCM7, Q8WUR3, Q91ZP0
      UniProtKB/TrEMBL
      Q3UEM7
      Related
      ENSMUSP00000037018.8, ENSMUST00000048486.13
      Conserved Domains (2) summary
      pfam08702
      Location:30171
      Fib_alpha; Fibrinogen alpha/beta chain family
      cl00085
      Location:174413
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      82915031..82922363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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