U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Myo6 myosin VI [ Mus musculus (house mouse) ]

    Gene ID: 17920, updated on 3-Dec-2024

    Summary

    Official Symbol
    Myo6provided by MGI
    Official Full Name
    myosin VIprovided by MGI
    Primary source
    MGI:MGI:104785
    See related
    Ensembl:ENSMUSG00000033577 AllianceGenome:MGI:104785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sv; Tlc; rsv; Myo6<rsv>
    Summary
    Predicted to enable actin filament binding activity; identical protein binding activity; and microfilament motor activity. Involved in postsynaptic neurotransmitter receptor internalization; presynaptic modulation of chemical synaptic transmission; and protein localization. Acts upstream of or within several processes, including cellular response to electrical stimulus; inner ear development; and nervous system development. Located in several cellular components, including brush border; neuronal cell body; and perinuclear region of cytoplasm. Is active in several cellular components, including Schaffer collateral - CA1 synapse; cochlear hair cell ribbon synapse; and postsynaptic actin cytoskeleton. Is expressed in cerebral cortex ventricular layer; ear; heart; skeletal muscle; and stomach. Used to study autosomal dominant nonsyndromic deafness 22 and autosomal recessive nonsyndromic deafness 37. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 13.1), placenta adult (RPKM 10.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Myo6 in Genome Data Viewer
    Location:
    9 E1; 9 43.98 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (80072262..80219011)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (80164976..80311729)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24753 Neighboring gene STARR-seq mESC enhancer starr_24754 Neighboring gene STARR-positive B cell enhancer ABC_E715 Neighboring gene STARR-positive B cell enhancer ABC_E8303 Neighboring gene predicted gene, 46146 Neighboring gene SUMO/sentrin specific peptidase 6 Neighboring gene STARR-positive B cell enhancer ABC_E3848 Neighboring gene predicted gene 27227 Neighboring gene STARR-seq mESC enhancer starr_24757 Neighboring gene interphotoreceptor matrix proteoglycan 1 Neighboring gene STARR-seq mESC enhancer starr_24758 Neighboring gene methyltransferase like 9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24759 Neighboring gene STARR-seq mESC enhancer starr_24760 Neighboring gene predicted gene, 39380

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to electrical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glutamate secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inner ear auditory receptor cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within inner ear auditory receptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inner ear morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein targeting IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with clathrin-coated endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cochlear hair cell ribbon synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of filamentous actin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic actin cytoskeleton IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in presynaptic endocytic zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in vesicle membrane IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    unconventional myosin-VI
    Names
    Snell's waltzer
    protein twist
    tailchaser
    unconventional myosin-6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039546.3NP_001034635.2  unconventional myosin-VI isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC120388, AC159738
      Consensus CDS
      CCDS23368.1
      UniProtKB/Swiss-Prot
      E9Q3L1, Q64331
      UniProtKB/TrEMBL
      B2RWR8
      Related
      ENSMUSP00000036181.9, ENSMUST00000035889.15
      Conserved Domains (3) summary
      smart00242
      Location:52771
      MYSc; Myosin. Large ATPases
      cd01382
      Location:71759
      MYSc_Myo6; class VI myosin, motor domain
      pfam16521
      Location:11451235
      Myosin-VI_CBD; Myosin VI cargo binding domain
    2. NM_001408252.1NP_001395181.1  unconventional myosin-VI isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC120388, AC159738
      UniProtKB/TrEMBL
      E9Q174, V9GX76, V9GXM4
      Related
      ENSMUSP00000139019.2, ENSMUST00000184480.8
    3. NM_001408253.1NP_001395182.1  unconventional myosin-VI isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC120388, AC159738
      UniProtKB/TrEMBL
      E9Q174, V9GXM4
      Related
      ENSMUSP00000075501.4, ENSMUST00000076140.4
    4. NM_001408255.1NP_001395184.1  unconventional myosin-VI isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC120388, AC159738
      UniProtKB/TrEMBL
      B2RWR8, E9Q175
      Related
      ENSMUSP00000108891.2, ENSMUST00000113266.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      80072262..80219011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510836.3XP_006510899.1  unconventional myosin-VI isoform X2

      UniProtKB/TrEMBL
      E9Q174, V9GXM4
      Conserved Domains (3) summary
      TIGR04211
      Location:845928
      SH3_and_anchor; SH3 domain protein
      cd01382
      Location:71759
      MYSc_Myo6; class VI myosin, motor domain
      pfam16521
      Location:11681258
      Myosin-VI_CBD; Myosin VI cargo binding domain
    2. XM_036154672.1XP_036010565.1  unconventional myosin-VI isoform X3

      UniProtKB/TrEMBL
      E9Q174
    3. XM_030244104.2XP_030099964.1  unconventional myosin-VI isoform X4

      UniProtKB/TrEMBL
      E9PVU0
      Conserved Domains (3) summary
      TIGR04211
      Location:845928
      SH3_and_anchor; SH3 domain protein
      cd01382
      Location:71759
      MYSc_Myo6; class VI myosin, motor domain
      pfam16521
      Location:11551245
      Myosin-VI_CBD; Myosin VI cargo binding domain

    RNA

    1. XR_004935336.1 RNA Sequence

    2. XR_004935335.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_008662.1: Suppressed sequence

      Description
      NM_008662.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.