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    Nrip2 nuclear receptor interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 60345, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nrip2provided by MGI
    Official Full Name
    nuclear receptor interacting protein 2provided by MGI
    Primary source
    MGI:MGI:1891884
    See related
    Ensembl:ENSMUSG00000001520 AllianceGenome:MGI:1891884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NIX1
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within Notch signaling pathway and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in brain and heart. Orthologous to human NRIP2 (nuclear receptor interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 9.0), frontal lobe adult (RPKM 3.6) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nrip2 in Genome Data Viewer
    Location:
    6 F3; 6 62.99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128374780..128386747)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128397818..128409780)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene forkhead box M1 Neighboring gene STARR-positive B cell enhancer ABC_E8833 Neighboring gene testis expressed 52 Neighboring gene STARR-positive B cell enhancer ABC_E4868 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4869 Neighboring gene FK506 binding protein 4 Neighboring gene predicted gene 10069 Neighboring gene STAM binding protein, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of β-Catenin During Podocyte Injury. Hou Q, et al. Front Cell Dev Biol, 2021. PMID 35004680, Free PMC Article
    2. Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor. Greiner EF, et al. Proc Natl Acad Sci U S A, 2000 Jun 20. PMID 10860982, Free PMC Article
    3. Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Fouillade C, et al. Arterioscler Thromb Vasc Biol, 2013 Jan. PMID 23117660, Free PMC Article
    4. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144354

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear receptor-interacting protein 2
    Names
    neuronal interacting factor 1
    neuronal-interacting factor X 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162858.2 → NP_001156330.1  nuclear receptor-interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001156330.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC116573
      Consensus CDS
      CCDS51917.1
      UniProtKB/Swiss-Prot
      Q14BZ2, Q3U0V7, Q3UYH0, Q9JHR9
      Related
      ENSMUSP00000113317.2, ENSMUST00000120405.4
      Conserved Domains (1) summary
      cl11403
      Location:110 → 199
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    2. NM_001411379.1 → NP_001398308.1  nuclear receptor-interacting protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116573
      UniProtKB/TrEMBL
      E9QAD1

    3. NM_001411380.1 → NP_001398309.1  nuclear receptor-interacting protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116573

    4. NM_021717.3 → NP_068363.2  nuclear receptor-interacting protein 2 isoform 2

      See identical proteins and their annotated locations for NP_068363.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1, that results in a frameshift. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AC116573
      Consensus CDS
      CCDS20571.1
      UniProtKB/TrEMBL
      E9QAD1
      Related
      ENSMUSP00000001561.6, ENSMUST00000001561.12
      Conserved Domains (1) summary
      cl11403
      Location:110 → 206
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      128374780..128386747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506451.5 → XP_006506514.1  nuclear receptor-interacting protein 2 isoform X3

      UniProtKB/TrEMBL
      E9QAD1
      Conserved Domains (1) summary
      cl11403
      Location:110 → 199
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    2. XM_006506449.5 → XP_006506512.1  nuclear receptor-interacting protein 2 isoform X1

      UniProtKB/TrEMBL
      E9QAD1
      Related
      ENSMUSP00000122558.2, ENSMUST00000123867.8
      Conserved Domains (1) summary
      cl11403
      Location:127 → 216
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    3. XM_036152249.1 → XP_036008142.1  nuclear receptor-interacting protein 2 isoform X4

      Conserved Domains (1) summary
      cl11403
      Location:64 → 149
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    4. XM_036152250.1 → XP_036008143.1  nuclear receptor-interacting protein 2 isoform X5

      Conserved Domains (1) summary
      cl11403
      Location:64 → 156
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHR9.2 GenPept UniProtKB/Swiss-Prot:Q9JHR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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