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    Phkg1 phosphorylase kinase gamma 1 [ Mus musculus (house mouse) ]

    Gene ID: 18682, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Phkg1provided by MGI
    Official Full Name
    phosphorylase kinase gamma 1provided by MGI
    Primary source
    MGI:MGI:97579
    See related
    Ensembl:ENSMUSG00000025537 AllianceGenome:MGI:97579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Phkg
    Summary
    Enables phosphorylase kinase activity. Predicted to be involved in glycogen catabolic process; positive regulation of glycogen catabolic process; and signal transduction. Predicted to be part of phosphorylase kinase complex. Predicted to be active in cytoplasm. Is expressed in cerebral cortex; heart; and liver. Orthologous to human PHKG1 (phosphorylase kinase catalytic subunit gamma 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 14.4), heart adult (RPKM 12.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Phkg1 in Genome Data Viewer
    Location:
    5 G1.3; 5 68.26 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129892272..129907953, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129863431..129879134, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 6A Neighboring gene predicted gene, 23245 Neighboring gene STARR-positive B cell enhancer ABC_E3624 Neighboring gene small nucleolar RNA, H/ACA box 15 Neighboring gene sulfatase modifying factor 2 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E125 Neighboring gene STARR-positive B cell enhancer ABC_E2766 Neighboring gene zinc finger BED-type containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Skeletal muscle phosphorylase kinase catalytic subunit mRNAs are expressed in heart tissue but not in liver. Bender PK, et al. J Biol Chem, 1987 Jun 25. PMID 3597394
    2. Two exons encode the calmodulin-binding domain in the mouse phosphorylase kinase catalytic subunit gene. Bender PK, et al. Genet Anal Tech Appl, 1993 Jun-Aug. PMID 8110484
    3. A B2 repeat insertion generates alternate structures of the mouse muscle gamma-phosphorylase kinase gene. Maichele AJ, et al. Genomics, 1993 Apr. PMID 8486349
    4. Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology. Amemiya T, et al. NPJ Syst Biol Appl, 2015. PMID 28725458, Free PMC Article
    5. Isolation of cDNA clones for the catalytic gamma subunit of mouse muscle phosphorylase kinase: expression of mRNA in normal and mutant Phk mice. Chamberlain JS, et al. Proc Natl Acad Sci U S A, 1987 May. PMID 3472241, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorylase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorylase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphorylase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in glycogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphorylase kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphorylase kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phosphorylase kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
    Names
    phosphorylase kinase subunit gamma-1
    serine/threonine-protein kinase PHKG1
    NP_035209.1
    XP_011239173.1
    XP_036020769.1
    XP_036020770.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011079.3 → NP_035209.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

      See identical proteins and their annotated locations for NP_035209.1

      Status: VALIDATED

      Source sequence(s)
      AC242408, BC055102
      Consensus CDS
      CCDS19701.1
      UniProtKB/Swiss-Prot
      P07934
      Related
      ENSMUSP00000026617.7, ENSMUST00000026617.13
      Conserved Domains (1) summary
      cl21453
      Location:16 → 291
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_145486.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC242408

    2. NR_145487.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC242408

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      129892272..129907953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240871.4 → XP_011239173.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 185
      PKc_like; Protein Kinases, catalytic domain

    2. XM_036164876.1 → XP_036020769.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 185
      PKc_like; Protein Kinases, catalytic domain

    3. XM_036164877.1 → XP_036020770.1  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 185
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07934.3 GenPept UniProtKB/Swiss-Prot:P07934

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