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    Epc2 enhancer of polycomb homolog 2 [ Mus musculus (house mouse) ]

    Gene ID: 227867, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Epc2provided by MGI
    Official Full Name
    enhancer of polycomb homolog 2provided by MGI
    Primary source
    MGI:MGI:1278321
    See related
    Ensembl:ENSMUSG00000069495 AllianceGenome:MGI:1278321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5830499L14; D2Ertd694e
    Summary
    Predicted to be involved in positive regulation of double-strand break repair via homologous recombination; regulation of cell cycle; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex; nucleosome; and piccolo histone acetyltransferase complex. Orthologous to human EPC2 (enhancer of polycomb homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 9.1), CNS E14 (RPKM 8.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Epc2 in Genome Data Viewer
    Location:
    2 C1.1; 2 28.62 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (49341498..49441954)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (49450755..49551947)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04438 Neighboring gene 40S ribosomal protein S3a pseudogene Neighboring gene STARR-seq mESC enhancer starr_04439 Neighboring gene predicted gene, 25215 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49307666-49307775 Neighboring gene STARR-positive B cell enhancer ABC_E807 Neighboring gene STARR-seq mESC enhancer starr_04442 Neighboring gene kinesin family member 5C Neighboring gene STARR-positive B cell enhancer mm9_chr2:49589986-49590287 Neighboring gene predicted gene, 46738 Neighboring gene STARR-seq mESC enhancer starr_04444 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49672814-49673015 Neighboring gene LY6/PLAUR domain containing 6B Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49703331-49703484 Neighboring gene STARR-seq mESC enhancer starr_04445

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. Fisher CL, et al. Nucleic Acids Res, 2017 Dec 1. PMID 28981838, Free PMC Article
    2. The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals. Stankunas K, et al. Development, 1998 Oct. PMID 9735366
    3. A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum. Farini D, et al. Cell Rep, 2020 Jun 2. PMID 32492419
    4. Hdac6 regulates Tip60-p400 function in stem cells. Chen PB, et al. Elife, 2013 Dec 3. PMID 24302573, Free PMC Article
    5. The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation. Jacquet K, et al. Mol Cell, 2016 May 5. PMID 27153538, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp566F2124

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of piccolo histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    enhancer of polycomb homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172663.4 → NP_766251.3  enhancer of polycomb homolog 2

      See identical proteins and their annotated locations for NP_766251.3

      Status: VALIDATED

      Source sequence(s)
      AK031025, AK141073, AK164886, BB620197, BY253789
      Consensus CDS
      CCDS16023.1
      UniProtKB/Swiss-Prot
      A2AQU9, Q3URX9, Q80Y70, Q8BXC5, Q8C0I4
      Related
      ENSMUSP00000089758.5, ENSMUST00000092123.11
      Conserved Domains (2) summary
      pfam06752
      Location:578 → 808
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:7 → 148
      EPL1; Enhancer of polycomb-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      49341498..49441954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498011.4 → XP_006498074.1  enhancer of polycomb homolog 2 isoform X1

      Conserved Domains (2) summary
      pfam06752
      Location:514 → 744
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:7 → 148
      EPL1; Enhancer of polycomb-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0I4.2 GenPept UniProtKB/Swiss-Prot:Q8C0I4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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