Cyp2c55 cytochrome P450, family 2, subfamily c, polypeptide 55 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2c55provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily c, polypeptide 55provided by MGI
Primary source: MGI:MGI:1919332
See related: Ensembl:ENSMUSG00000025002 AllianceGenome:MGI:1919332
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CYPIIC55; 2010318C06Rik
Summary: Enables arachidonate epoxygenase activity and linoleic acid epoxygenase activity. Acts upstream of or within arachidonate metabolic process and linoleic acid metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human CYP2C18 (cytochrome P450 family 2 subfamily C member 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward colon adult (RPKM 170.4) See more
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Genomic context

Location:: 19 C3; 19 33.64 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (38995384..39031134)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (39006940..39042690)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of intestinal Cyp2c55 is regulated by the microbiota and inflammation.
Title: The expression of intestinal Cyp2c55 is regulated by the microbiota and inflammation.
The mechanism of regulation of CYP2C55 and other detoxifying systems in Cyp3a(-/-) mice is reported.
Title: Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Cyp2c55 (e-PCR), detects polymorphism
- UniSTS:546721

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonate epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables linoleic acid epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables retinoic acid 4-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within linoleic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450 2C55

Names: cytochrome P450, 2c55

NP_082365.1

EC 1.14.14.1

XP_006527418.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.