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    Cdkl4 cyclin dependent kinase like 4 [ Mus musculus (house mouse) ]

    Gene ID: 381113, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdkl4provided by MGI
    Official Full Name
    cyclin dependent kinase like 4provided by MGI
    Primary source
    MGI:MGI:3587025
    See related
    Ensembl:ENSMUSG00000033966 AllianceGenome:MGI:3587025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm942
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of cell cycle. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; reproductive system; respiratory system; and skeleton. Orthologous to human CDKL4 (cyclin dependent kinase like 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 4.7), cortex adult (RPKM 1.8) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdkl4 in Genome Data Viewer
    Location:
    17 E3; 17 50.9 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80830979..80885242, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80523550..80577813, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E8924 Neighboring gene STARR-positive B cell enhancer ABC_E2500 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8925 Neighboring gene alkaline phosphatase, intestinal pseudogene Neighboring gene STARR-seq mESC enhancer starr_43318 Neighboring gene STARR-positive B cell enhancer ABC_E5633 Neighboring gene STARR-positive B cell enhancer ABC_E10973 Neighboring gene STARR-positive B cell enhancer ABC_E9172 Neighboring gene STARR-positive B cell enhancer ABC_E4229 Neighboring gene STARR-positive B cell enhancer ABC_E616 Neighboring gene STARR-seq mESC enhancer starr_43322 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 3 Neighboring gene STARR-seq mESC enhancer starr_43326 Neighboring gene STARR-seq mESC enhancer starr_43329 Neighboring gene predicted gene 9959 Neighboring gene STARR-positive B cell enhancer mm9_chr17:81171844-81172145 Neighboring gene STARR-seq mESC enhancer starr_43332 Neighboring gene predicted gene, 33538

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase-like 4
    NP_001028615.1
    NP_001347072.1
    NP_001347073.1
    XP_006524592.1
    XP_006524593.1
    XP_006524594.1
    XP_006524595.1
    XP_011244823.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033443.4 → NP_001028615.1  cyclin-dependent kinase-like 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC131712
      Consensus CDS
      CCDS28992.1
      UniProtKB/Swiss-Prot
      B2RSS7, Q3TZA2
      Related
      ENSMUSP00000083732.5, ENSMUST00000086545.5
      Conserved Domains (1) summary
      cd07847
      Location:2 → 286
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    2. NM_001360143.1 → NP_001347072.1  cyclin-dependent kinase-like 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC131712
      Consensus CDS
      CCDS28992.1
      UniProtKB/Swiss-Prot
      B2RSS7, Q3TZA2
      Related
      ENSMUSP00000157316.2, ENSMUST00000234349.2
      Conserved Domains (1) summary
      cd07847
      Location:2 → 286
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    3. NM_001360144.1 → NP_001347073.1  cyclin-dependent kinase-like 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC131712
      Consensus CDS
      CCDS28992.1
      UniProtKB/Swiss-Prot
      B2RSS7, Q3TZA2
      Related
      ENSMUSP00000157063.2, ENSMUST00000234602.2
      Conserved Domains (1) summary
      cd07847
      Location:2 → 286
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      80830979..80885242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524529.3 → XP_006524592.1  cyclin-dependent kinase-like 4 isoform X2

      Conserved Domains (1) summary
      cd07847
      Location:2 → 285
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    2. XM_011246521.3 → XP_011244823.1  cyclin-dependent kinase-like 4 isoform X1

      UniProtKB/Swiss-Prot
      B2RSS7, Q3TZA2
      Conserved Domains (1) summary
      cd07847
      Location:2 → 286
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    3. XM_006524531.2 → XP_006524594.1  cyclin-dependent kinase-like 4 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:2 → 148
      PKc_like; Protein Kinases, catalytic domain

    4. XM_006524530.1 → XP_006524593.1  cyclin-dependent kinase-like 4 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:2 → 193
      PKc_like; Protein Kinases, catalytic domain

    5. XM_006524532.5 → XP_006524595.1  cyclin-dependent kinase-like 4 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:2 → 148
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_003952147.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TZA2.1 GenPept UniProtKB/Swiss-Prot:Q3TZA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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