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    Trem1 triggering receptor expressed on myeloid cells 1 [ Mus musculus (house mouse) ]

    Gene ID: 58217, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trem1provided by MGI
    Official Full Name
    triggering receptor expressed on myeloid cells 1provided by MGI
    Primary source
    MGI:MGI:1930005
    See related
    Ensembl:ENSMUSG00000042265 AllianceGenome:MGI:1930005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable receptor decoy activity; scaffold protein binding activity; and transmembrane signaling receptor activity. Acts upstream of or within neutrophil chemotaxis; neutrophil extravasation; and neutrophil-mediated killing of gram-negative bacterium. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracellular space. Is expressed in bladder and renal vasculature. Human ortholog(s) of this gene implicated in bacterial pneumonia; bacterial sepsis; malaria; and myocardial infarction. Orthologous to human TREM1 (triggering receptor expressed on myeloid cells 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 1.2), liver E18 (RPKM 1.1) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trem1 in Genome Data Viewer
    Location:
    17 C; 17 23.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48539763..48553955)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48232713..48246927)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9830107B12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48237942-48238143 Neighboring gene STARR-positive B cell enhancer ABC_E9956 Neighboring gene STARR-seq mESC enhancer starr_42745 Neighboring gene RIKEN cDNA A530064D06 gene Neighboring gene STARR-seq mESC enhancer starr_42746 Neighboring gene STARR-seq mESC enhancer starr_42747 Neighboring gene predicted gene, 52308 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene predicted gene, 52307 Neighboring gene triggering receptor expressed on myeloid cells 3 Neighboring gene triggering receptor expressed on myeloid cells-like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TREM-1 activation modulates dsRNA induced antiviral immunity with specific enhancement of MAPK signaling and the RLRs and TLRs on macrophages. Zhu J, et al. Exp Cell Res, 2016 Jul 1. PMID 27237091
    2. Activation of TREM-1 induces endoplasmic reticulum stress through IRE-1α/XBP-1s pathway in murine macrophages. Dong L, et al. Mol Immunol, 2021 Jul. PMID 33957479
    3. Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis. Boufenzer A, et al. Cell Mol Immunol, 2021 Feb. PMID 33420354, Free PMC Article
    4. TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm. Vandestienne M, et al. J Clin Invest, 2021 Jan 19. PMID 33258804, Free PMC Article
    5. TREM-1 enhances Mycobacterium tuberculosis-induced inflammatory responses in macrophages. Feng JY, et al. Microbes Infect, 2021 Jan-Feb. PMID 33049389

    See all (131) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-Cell RNA Sequencing Reveals Transcriptional Landscape of Neutrophils and Highlights the Role of TREM-1 in EAE.
      Title: Single-Cell RNA Sequencing Reveals Transcriptional Landscape of Neutrophils and Highlights the Role of TREM-1 in EAE.
    2. TREM1 facilitates the development of gastric cancer through regulating neutrophil extracellular traps-mediated macrophage polarization.
      Title: TREM1 facilitates the development of gastric cancer through regulating neutrophil extracellular traps-mediated macrophage polarization.
    3. TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models.
      Title: TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models.
    4. Systemic neutrophils are triggered by respiratory Bacillus Calmette- Guerin and mediate pulmonary mycobacterial clearance in synergy with the triggering receptor expressed on myeloid cells 1.
      Title: Systemic neutrophils are triggered by respiratory Bacillus Calmette- Guérin and mediate pulmonary mycobacterial clearance in synergy with the triggering receptor expressed on myeloid cells 1.
    5. Endothelial TREM-1 receptor regulates the blood-brain barrier integrity after intracerebral hemorrhage in mice via SYK/beta-catenin signaling.
      Title: Endothelial TREM-1 receptor regulates the blood-brain barrier integrity after intracerebral hemorrhage in mice via SYK/β-catenin signaling.
    6. Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis.
      Title: Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis.
    7. TREM1 activation of myeloid cells promotes antitumor immunity.
      Title: TREM1 activation of myeloid cells promotes antitumor immunity.
    8. The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis.
      Title: The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis.
    9. Inhibition of TREM-1 ameliorates Lipopolysaccharide-induced depressive-like behaviors by alleviating neuroinflammation in the PFC via PI3K/Akt signaling pathway.
      Title: Inhibition of TREM-1 ameliorates Lipopolysaccharide-induced depressive-like behaviors by alleviating neuroinflammation in the PFC via PI3K/Akt signaling pathway.
    10. Radiation upregulates macrophage TREM-1 expression to exacerbate injury in mice.
      Title: Radiation upregulates macrophage TREM-1 expression to exacerbate injury in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (96)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables receptor decoy activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chemokine production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokine production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cytokine production involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytokine production involved in immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neutrophil chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neutrophil extravasation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neutrophil migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neutrophil-mediated killing of gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neutrophil-mediated killing of gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    triggering receptor expressed on myeloid cells 1
    Names
    triggering receptor expressed in monocytes 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347399.1 → NP_001334328.1  triggering receptor expressed on myeloid cells 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC241601
      Consensus CDS
      CCDS84319.1
      UniProtKB/TrEMBL
      Q14DT9
      Related
      ENSMUSP00000108877.4, ENSMUST00000113251.10

    2. NM_021406.5 → NP_067381.1  triggering receptor expressed on myeloid cells 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_067381.1

      Status: VALIDATED

      Source sequence(s)
      AC241601, AK089439
      Consensus CDS
      CCDS28860.1
      UniProtKB/Swiss-Prot
      Q3TAL7, Q9JKE2
      Related
      ENSMUSP00000038636.7, ENSMUST00000048782.7
      Conserved Domains (2) summary
      smart00410
      Location:32 → 133
      IG_like; Immunoglobulin like
      pfam07686
      Location:32 → 134
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48539763..48553955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524729.5 → XP_006524792.1  triggering receptor expressed on myeloid cells 1 isoform X3

      Conserved Domains (1) summary
      pfam07686
      Location:32 → 134
      V-set; Immunoglobulin V-set domain

    2. XM_036160714.1 → XP_036016607.1  triggering receptor expressed on myeloid cells 1 isoform X1

      Conserved Domains (2) summary
      cd00096
      Location:28 → 33
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:25 → 132
      Ig; Immunoglobulin domain

    3. XM_006524728.4 → XP_006524791.1  triggering receptor expressed on myeloid cells 1 isoform X2

      See identical proteins and their annotated locations for XP_006524791.1

      Conserved Domains (1) summary
      pfam07686
      Location:1 → 89
      V-set; Immunoglobulin V-set domain

    4. XM_006524726.5 → XP_006524789.1  triggering receptor expressed on myeloid cells 1 isoform X2

      See identical proteins and their annotated locations for XP_006524789.1

      Conserved Domains (1) summary
      pfam07686
      Location:1 → 89
      V-set; Immunoglobulin V-set domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKE2.1 GenPept UniProtKB/Swiss-Prot:Q9JKE2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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