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    Foxg1 forkhead box G1 [ Mus musculus (house mouse) ]

    Gene ID: 15228, updated on 9-Dec-2024

    Summary

    Official Symbol
    Foxg1provided by MGI
    Official Full Name
    forkhead box G1provided by MGI
    Primary source
    MGI:MGI:1347464
    See related
    Ensembl:ENSMUSG00000020950 AllianceGenome:MGI:1347464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bf1; BF-1; Hfh9; Hfhbf1; 2900064B05Rik
    Summary
    Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including neuron differentiation; positive regulation of neuroblast proliferation; and regulation of neuron differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; early embryo; embryo ectoderm; gonad; and sensory organ. Used to study Rett syndrome. Orthologous to human FOXG1 (forkhead box G1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E14 (RPKM 45.4), whole brain E14.5 (RPKM 34.5) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Foxg1 in Genome Data Viewer
    Location:
    12 B3; 12 21.78 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (49429666..49433650)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (49382883..49386867)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene predicted gene, 34304 Neighboring gene RIKEN cDNA 3110039M20 gene Neighboring gene predicted gene, 34381

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within axon midline choice point recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neurogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron fate determination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within pyramidal neuron migration to cerebral cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neural precursor cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    forkhead box protein G1
    Names
    HNF-3/forkhead homolog, brain factor 1
    forkhead-related protein FKHL1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160112.1NP_001153584.1  forkhead box protein G1

      See identical proteins and their annotated locations for NP_001153584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the one-exon transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC162376, AK132305, AV226567, BC046958
      Consensus CDS
      CCDS25899.1
      UniProtKB/Swiss-Prot
      Q60987, Q80VP3
      UniProtKB/TrEMBL
      Q3V1Q8
      Related
      ENSMUSP00000136372.2, ENSMUST00000179669.3
      Conserved Domains (1) summary
      smart00339
      Location:173261
      FH; FORKHEAD
    2. NM_008241.2NP_032267.1  forkhead box protein G1

      See identical proteins and their annotated locations for NP_032267.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the 2-exon transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AV226567, BC046958, CA320871, U36760
      Consensus CDS
      CCDS25899.1
      UniProtKB/Swiss-Prot
      Q60987, Q80VP3
      UniProtKB/TrEMBL
      Q3V1Q8
      Related
      ENSMUSP00000021333.4, ENSMUST00000021333.5
      Conserved Domains (1) summary
      smart00339
      Location:173261
      FH; FORKHEAD

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      49429666..49433650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)