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    Tefm transcription elongation factor, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 68550, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tefmprovided by MGI
    Official Full Name
    transcription elongation factor, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1915800
    See related
    Ensembl:ENSMUSG00000046909 AllianceGenome:MGI:1915800
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110002N22Rik
    Summary
    Predicted to enable DNA polymerase processivity factor activity. Predicted to be involved in mitochondrial transcription and oxidative phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human TEFM (transcription elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 3.7), CNS E11.5 (RPKM 3.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tefm in Genome Data Viewer
    Location:
    11 B5; 11 47.53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80027500..80033697, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80136674..80142871, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cytokine receptor-like factor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:79881110-79881263 Neighboring gene STARR-seq mESC enhancer starr_30136 Neighboring gene ATPase family, AAA domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_30137 Neighboring gene STARR-seq mESC enhancer starr_30138 Neighboring gene ArfGAP with dual PH domains 2 Neighboring gene ArfGAP with dual PH domains 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_30143 Neighboring gene STARR-positive B cell enhancer ABC_E7025 Neighboring gene ring finger protein 135

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TEFM regulates both transcription elongation and RNA processing in mitochondria. Jiang S, et al. EMBO Rep, 2019 Jun. PMID 31036713, Free PMC Article
    2. Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. Jenne DE, et al. Genes Chromosomes Cancer, 2003 Jun. PMID 12696059
    3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ22729

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA polymerase processivity factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA polymerase processivity factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA polymerase processivity factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxidative phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription elongation by mitochondrial RNA polymerase IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial nucleoid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183275.2 → NP_899098.2  transcription elongation factor, mitochondrial

      See identical proteins and their annotated locations for NP_899098.2

      Status: VALIDATED

      Source sequence(s)
      AK146639, BE949440
      Consensus CDS
      CCDS36241.1
      UniProtKB/Swiss-Prot
      Q5SSK3
      Related
      ENSMUSP00000059304.10, ENSMUST00000050207.10
      Conserved Domains (1) summary
      cl22429
      Location:80 → 128
      HHH_5; Helix-hairpin-helix domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      80027500..80033697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249204.3 → XP_011247506.1  transcription elongation factor, mitochondrial isoform X1

      Conserved Domains (2) summary
      cl21482
      Location:192 → 375
      RuvC_like; Crossover junction endodeoxyribonuclease RuvC and similar proteins
      cl22429
      Location:80 → 128
      HHH_5; Helix-hairpin-helix domain

    2. XM_030246262.1 → XP_030102122.1  transcription elongation factor, mitochondrial isoform X2

      UniProtKB/TrEMBL
      Q8BTE4

    3. XM_011249205.1 → XP_011247507.1  transcription elongation factor, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_011247507.1

      UniProtKB/TrEMBL
      Q8BTE4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SSK3.1 GenPept UniProtKB/Swiss-Prot:Q5SSK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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