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    Ccnq cyclin Q [ Mus musculus (house mouse) ]

    Gene ID: 69109, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ccnqprovided by MGI
    Official Full Name
    cyclin Qprovided by MGI
    Primary source
    MGI:MGI:1916359
    See related
    Ensembl:ENSMUSG00000049489 AllianceGenome:MGI:1916359
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam58a; Fam58b; 1810009O10Rik
    Summary
    Enables protein kinase activator activity. Acts upstream of or within positive regulation of MAPK cascade. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; heart; pancreas; and retina. Human ortholog(s) of this gene implicated in syndactyly-telecanthus-anogenital and renal malformations syndrome. Orthologous to human CCNQ (cyclin Q). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See Ccnq in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78641332..78642555, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78750506..78751729, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene nemo like kinase Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_30101 Neighboring gene STARR-positive B cell enhancer ABC_E1143 Neighboring gene STARR-positive B cell enhancer ABC_E2361 Neighboring gene 40S ribosomal protein SA-like Neighboring gene STARR-seq mESC enhancer starr_30102 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78585506-78585689 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78643849-78644032 Neighboring gene predicted gene, 23219 Neighboring gene LYR motif containing 9

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    General protein information

    Preferred Names
    cyclin-Q
    Names
    CDK10-activating cyclin
    cyclin M
    cyclin-related protein FAM58A
    cyclin-related protein FAM58B
    family with sequence similarity 58, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_197989.1NP_932106.1  cyclin-Q

      See identical proteins and their annotated locations for NP_932106.1

      Status: VALIDATED

      Source sequence(s)
      BC027022
      Consensus CDS
      CCDS25114.1
      UniProtKB/Swiss-Prot
      Q8QZR8
      Related
      ENSMUSP00000050658.5, ENSMUST00000059468.6
      Conserved Domains (2) summary
      COG5333
      Location:35248
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
      cd00043
      Location:34131
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78641332..78642555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)