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    Ggt6 gamma-glutamyltransferase 6 [ Mus musculus (house mouse) ]

    Gene ID: 71522, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ggt6provided by MGI
    Official Full Name
    gamma-glutamyltransferase 6provided by MGI
    Primary source
    MGI:MGI:1918772
    See related
    Ensembl:ENSMUSG00000040471 AllianceGenome:MGI:1918772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030405D14Rik
    Summary
    Predicted to enable glutathione hydrolase activity and leukotriene C4 gamma-glutamyl transferase activity. Predicted to be involved in glutathione biosynthetic process. Predicted to be located in membrane. Is expressed in alimentary system; integumental system; and nervous system. Orthologous to human GGT6 (gamma-glutamyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 26.9), duodenum adult (RPKM 15.9) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ggt6 in Genome Data Viewer
    Location:
    11 B4; 11 44.27 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72326067..72329392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72435247..72438566)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 6338 Neighboring gene smoothelin-like 2 Neighboring gene STARR-seq mESC enhancer starr_29906 Neighboring gene STARR-positive B cell enhancer ABC_E10683 Neighboring gene STARR-positive B cell enhancer ABC_E8422 Neighboring gene MYB binding protein (P160) 1a Neighboring gene SPNS lysolipid transporter 2, sphingosine-1-phosphate Neighboring gene Spns2 opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene C4 gamma-glutamyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione hydrolase 6
    Names
    GGT 6
    gamma-glutamyltranspeptidase 6
    NP_001404948.1
    NP_001404949.1
    NP_001404950.1
    NP_082095.2
    XP_006534304.1
    XP_006534307.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418019.1 → NP_001404948.1  glutathione hydrolase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL662812

    2. NM_001418020.1 → NP_001404949.1  glutathione hydrolase 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL662812

    3. NM_001418021.1 → NP_001404950.1  glutathione hydrolase 6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL662812
      UniProtKB/TrEMBL
      A7DTG9
      Related
      ENSMUSP00000104139.2, ENSMUST00000108499.2

    4. NM_027819.3 → NP_082095.2  glutathione hydrolase 6 isoform 1

      See identical proteins and their annotated locations for NP_082095.2

      Status: VALIDATED

      Source sequence(s)
      AL662812
      Consensus CDS
      CCDS36216.1
      UniProtKB/Swiss-Prot
      Q5F245, Q6PDE7, Q9D347
      Related
      ENSMUSP00000075773.4, ENSMUST00000076443.10
      Conserved Domains (1) summary
      cl19223
      Location:125 → 446
      G_glu_transpept; Gamma-glutamyltranspeptidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72326067..72329392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534244.5 → XP_006534307.1  glutathione hydrolase 6 isoform X4

      Conserved Domains (1) summary
      cl19223
      Location:114 → 235
      G_glu_transpept; Gamma-glutamyltranspeptidase

    2. XM_006534241.5 → XP_006534304.1  glutathione hydrolase 6 isoform X1

      Conserved Domains (1) summary
      cl19223
      Location:138 → 459
      G_glu_transpept; Gamma-glutamyltranspeptidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDE7.1 GenPept UniProtKB/Swiss-Prot:Q6PDE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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