Hal histidine ammonia lyase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Halprovided by MGI
Official Full Name: histidine ammonia lyaseprovided by MGI
Primary source: MGI:MGI:96010
See related: Ensembl:ENSMUSG00000020017 AllianceGenome:MGI:96010
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hsd; his; histidase
Summary: This gene encodes a member of the histidase protein family. The encoded protein is a cytosolic enzyme which catalyzes the first reaction in histidine catabolism. Defects in this protein cause histidinemia, which is characterized by increased histidine in blood, urine, and cerebrospinal fluid. [provided by RefSeq, Dec 2015]
Expression: Restricted expression toward liver adult (RPKM 120.3) See more
Orthologs: human all
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Genomic context

Location:: 10 C2; 10 48.49 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (93324630..93352623)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (93488768..93516761)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

photoprotective role of endogenous urocanic acid in the murine skin using histidinemic mice, in which the gene encoding histidase is mutated
Title: Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Spontaneous (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L07645 (e-PCR)
- UniSTS:180104

ha2147 (e-PCR)
- UniSTS:515490

RH142423 (e-PCR)
- UniSTS:231670

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histidine ammonia-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histidine ammonia-lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables histidine ammonia-lyase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-histidine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-histidine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-histidine catabolic process to glutamate and formamide	IEA Inferred from Electronic Annotation more info
involved_in L-histidine catabolic process to glutamate and formate	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histidine ammonia-lyase

NP_034531.1

EC 4.3.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.